A comparison of heparin and new anticoagulants for cardiopulmonary bypass surgery

被引：1
作者：
Belougne-Malfattie, E
Aguejouf, O
Labrousse, L
Doutremepuich, C
机构：
[1] Univ Victor Segalen Bordeaux 2, Fac Pharm, Hematol Lab, F-33076 Bordeaux, France
[2] Hop Cardiol Haut Leveque, Dept Cardiovasc Surg, Pessac, France
来源：
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 1998年 / 4卷 / 02期
关键词：
heparin; new anticoagulants; heparin derivatives; cardiopulmonary bypass surgery;
D O I：
10.1177/107602969800400208
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Heparin is still the major anticoagulant of choice during CPB, but it may cause thrombocytopenia and severe bleeding in patients. In light of these complications, the development of new anticoagulant drugs seemed to be necessary for these patients. Many experimental studies focused on r-hirudin, which presented a less hemorrhagic effect than heparin. However, neither antagonist has been shown to reverse this effect.
引用
收藏
页码：118 / 125
页数：8
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