Akt activity in Alzheimer's disease and other neurodegenerative disorders

被引：150
作者：
Rickle, A
Bogdanovic, N
Volkman, I
Winblad, B
Ravid, R
Cowburn, RF
机构：
[1] KASPAC, Neurotec, Novum, S-14157 Huddinge, Sweden
[2] Netherlands Brain Bank, Amsterdam, Netherlands
来源：
NEUROREPORT | 2004年 / 15卷 / 06期
关键词：
Alzheimer's disease; Akt; apoptosis; IGF-I; post mortem brain;
D O I：
10.1097/00001756-200404290-00005
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Enzyme activities of the serine/threonine kinase Akt were compared in mid-temporal and mid-frontal cortices from Alzheimer's disease cases and matched controls. Activities (GSK-3alpha/beta fusion protein phosphorylation by immunoprecipitated Akt) were significantly increased in temporal cortex soluble fractions from Alzheimer's disease compared with non-disease controls and positive disease controls with another neurodegenerative disease. Temporal cortex soluble fraction Akt activities positively correlated with Braak staging for neurofibrillary changes. Frontal cortex soluble fraction activities were significantly reduced in positive disease compared with Alzheimer's disease cases and non-disease controls. Strong Ser(473) Akt immunoreactivity was seen in Alzheimer's disease pyramidal neurons likely undergoing degeneration and in reactive astroglia. Non-disease and positive disease controls showed moderate Ser(473) Akt immunostaining of occasional pyramidal neurons.
引用
收藏
页码：955 / 959
页数：5
相关论文
共 13 条
  • [1] GSK3β signalling:: Casting a wide net in Alzheimer's disease
    Bhat, RV
    Budd, SL
    [J]. NEUROSIGNALS, 2002, 11 (05) : 251 - 261
  • [2] Ten years of protein kinase B signalling: a hard Akt to follow
    Brazil, DP
    Hemmings, BA
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 2001, 26 (11) : 657 - 664
  • [3] Protective and rescuing abilities of IGF-I and some putative free radical scavengers against β-amyloid-inducing toxicity in neurons
    Doré, S
    Bastianetto, S
    Kar, S
    Quirion, R
    [J]. NEUROPROTECTIVE AGENTS: FOURTH INTERNATIONAL CONFERENCE, 1999, 890 : 356 - 364
  • [4] Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration
    Ferrer, I
    Barrachina, M
    Puig, B
    [J]. ACTA NEUROPATHOLOGICA, 2002, 104 (06) : 583 - 591
  • [5] The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
    Grimes, CA
    Jope, RS
    [J]. PROGRESS IN NEUROBIOLOGY, 2001, 65 (04) : 391 - 426
  • [6] FRAT1 peptide decreases Aβ production in swAPP751 cells
    Li, BL
    Ryder, J
    Su, Y
    Zhou, Y
    Liu, F
    Ni, BH
    [J]. FEBS LETTERS, 2003, 553 (03) : 347 - 350
  • [7] Distribution of active glycogen synthase kinase 3β (GSK-3β) in brains staged for Alzheimer disease neurofibrillary changes
    Pei, JJ
    Braak, E
    Braak, H
    Grundke-Iqbal, I
    Iqbal, K
    Winblad, B
    Cowburn, RF
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1999, 58 (09) : 1010 - 1019
  • [8] Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain
    Pei, JJ
    Tanaka, T
    Tung, YC
    Braak, E
    Iqbal, K
    GrundkeIqbal, I
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1997, 56 (01) : 70 - 78
  • [9] Role of protein kinase B in Alzheimer's neurofibrillary pathology
    Pei, JJ
    Khatoon, S
    An, WL
    Nordlinder, M
    Tanaka, T
    Braak, H
    Tsujio, I
    Takeda, M
    Alafuzoff, I
    Winblad, B
    Cowburn, RF
    Grundke-Iqbal, I
    Iqbal, K
    [J]. ACTA NEUROPATHOLOGICA, 2003, 105 (04) : 381 - 392
  • [10] GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
    Phiel, CJ
    Wilson, CA
    Lee, VMY
    Klein, PS
    [J]. NATURE, 2003, 423 (6938) : 435 - 439
12