The translational challenges of precision oncology

被引：56

作者：

Pich, Oriol ^{[1
]}

Bailey, Chris ^{[1
]}

Watkins, Thomas B. K. ^{[1
]}

Zaccaria, Simone ^{[2
,3
]}

Jamal-Hanjani, Mariam ^{[2
,4
,5
]}

Swanton, Charles ^{[1
]}

机构：

[1] Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England

[2] UCL, Canc Res UK Lung Canc Ctr Excellence, Canc Inst, London, England

[3] UCL, Computat Canc Genom Res Grp, Canc Inst, London, England

[4] UCL, Canc Metastasis Lab, Canc Inst, London, England

[5] Univ Coll London Hosp, Dept Med Oncol, London, England

来源：

CANCER CELL | 2022年 / 40卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金; 欧洲研究理事会;

关键词：

BREAST-CANCER PREVENTION; CELL LUNG-CANCER; IMMUNE CHECKPOINT BLOCKADE; GENOME-WIDE ASSOCIATION; COLORECTAL-CANCER; CLONAL EVOLUTION; CHROMOSOMAL INSTABILITY; MUTATIONAL SIGNATURES; ACQUIRED-RESISTANCE; SOMATIC MUTATION;

D O I：

10.1016/j.ccell.2022.04.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The translational challenges in the field of precision oncology are in part related to the biological complexity and diversity of this disease. Technological advances in genomics have facilitated large sequencing efforts and discoveries that have further supported this notion. In this review, we reflect on the impact of these dis-coveries on our understanding of several concepts: cancer initiation, cancer prevention, early detection, adjuvant therapy and minimal residual disease monitoring, cancer drug resistance, and cancer evolution in metastasis. We discuss key areas of focus for improving cancer outcomes, from biological insights to clinical application, and suggest where the development of these technologies will lead us. Finally, we discuss practical challenges to the wider adoption of molecular profiling in the clinic and the need for robust translational infrastructure.

引用

页码：458 / 478

页数：21

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