Diagnostic potential of methylated DAPK in brushing samples of nasopharyngeal carcinoma

被引：5
作者：
Zhang, Jian [1 ]
Shen, Zhisen [1 ]
Liu, Huigao [2 ]
Liu, Shuai [3 ]
Shu, Wenxiu [4 ]
机构：
[1] Lihuili Hosp, Ningbo Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Ningbo, Zhejiang, Peoples R China
[2] Ningbo Zhenhai Longsai Hosp, Dept Otorhinolaryngol Head & Neck Surg, Ningbo, Zhejiang, Peoples R China
[3] Lihuili Eastern Hosp, Dept Radiol, Ningbo Med Ctr, Ningbo, Zhejiang, Peoples R China
[4] Lihuili Eastern Hosp, Dept Hematol & Oncol, Ningbo Med Ctr, 1111 JiangNan Rd, Ningbo, Zhejiang, Peoples R China
来源：
CANCER MANAGEMENT AND RESEARCH | 2018年 / 10卷
基金：
中国国家自然科学基金;
关键词：
death-associated protein kinase; methylation; nasopharyngeal carcinoma; diagnosis; TUMOR-SUPPRESSOR GENE; CPG-ISLAND METHYLATION; PROTEIN-KINASE GENE; PROMOTER HYPERMETHYLATION; COLORECTAL-CANCER; DNA METHYLATION; EPIGENETIC INACTIVATION; ABERRANT METHYLATION; PERIPHERAL-BLOOD; HUMAN NEOPLASIA;
D O I：
10.2147/CMAR.S171796
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The death-associated protein kinase (DAPK) gene is an important member of the apoptotic pathway and is inactivated by abnormal methylation in numerous cancers, including nasopharyngeal carcinoma (NPC). However, the diagnostic value of DAPK methylation in brushing samples and tissue samples of NPC remains unclear. Methods: We conducted a systematic meta-analysis based on 17 studies (including 386 tissue cases, 233 brushing cases, and 296 blood cases). Results: Our results revealed an association between methylated DAPK and increased risk of NPC in blood, brushing, and tissue samples. In addition, the comparison of the pooled sensitivity, specificity, and area under the curve of methylated DAPK in brushing and tissue samples demonstrated the non-inferior effectiveness of methylated DAPK in brushing samples to monitor the development of NPC.
引用
收藏
页码：2953 / 2964
页数：12
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