Development of Metformin Hydrochloride-Linagliptin Controlled Release Tablet Using Hydrophilic Polymers for Type 2 Diabetes in Asians

被引：0

作者：

Park, Sunjae ^{[1
]}

Kim, Pil Yun ^{[1
]}

Kim, Na Eun ^{[1
]}

Song, Youngeun ^{[1
]}

Jeon, Ga Young ^{[1
]}

Tumursukh, Nomin-Erdene ^{[1
]}

Song, Jeong Eun ^{[1
]}

Khang, Gilson ^{[1
,2
,3
]}

机构：

[1] Jeonbuk Natl Univ, Dept Bionanotechnol & Bioconvergence Engn, 567 Baekje daero, Jeonju 54896, South Korea

[2] Jeonbuk Natl Univ, Dept Polymer Nano Sci Technol, 567 Baekje daero, Jeonju 54896, South Korea

[3] Jeonbuk Natl Univ, Polymer Mat Fusion Res Ctr, 567 Baekje daero, Jeonju 54896, South Korea

来源：

POLYMER-KOREA | 2022年 / 46卷 / 02期

关键词：

metformin hydrochloride; linagliptin; wet granulation; poly(ethylene oxide); sustained release;

D O I：

10.7317/pk.2022.46.2.159

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Metformin hydrochloride, used for treatment of type 2 diabetes, is a drug belonging to the biopharmaceutical classification system III and has a high solubility in water. Therefore, hypoglycemia occurs in Asians who have lower weight and body fat than Westerners because of the rapid initial release. Accordingly, a hydrophilic polymer was used to reduce the risk of hypoglycemia due to the rapid increase in blood concentration of the drug, and a combination of metformin hydrochloride and linagliptin fixed -dose triple -layer tablet was prepared through a wet granulation process. The crystallinity and inclusion of drugs were evaluated through X-ray diffractometer (XRD), and chemical changes were confirmed through Fourier transform infrared spectroscopy (FTIR). Finally, tablets prepared by inducing a sustained release pattern and Trajenta duo tablets were analyzed by comparative dissolution test and confirmed to be available as type 2 diabetes treatments suitable for Asians.

引用

页码：159 / 164

页数：6

共 12 条

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