The macrostopper route: A new synthesis concept leading exclusively to diblock copolymers with enhanced DNA condensation potential

被引：20
作者：
Petersen, H
Martin, AL
Stolnik, S
Roberts, CJ
Davies, MC
Kissel, T
机构：
[1] Univ Marburg, Dept Pharmaceut & Biopharm, D-35032 Marburg, Germany
[2] Univ Nottingham, Sch Pharmaceut Sci, Nottingham NG7 2RD, England
来源：
MACROMOLECULES | 2002年 / 35卷 / 27期
关键词：
D O I：
10.1021/ma025625r
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The synthesis concept leading to diblock copolymers with enhanced DNA condensation potential was studied. It was found that the macrostopper concept led to diblock copolymers that enhance DNA condensation in comparison with homopolymer polyethylenimine (PEI) and multi-PEGylated PEI. Results showed that these PEG-b-PEI diblock copolymers were promising candidates for gene delivery.
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收藏
页码：9854 / 9856
页数：3
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