In vitro antibacterial and osteogenic properties of plasma sprayed silver-containing hydroxyapatite coating

被引：30
作者：
Ruan HongJiang [1 ]
Fan CunYi [1 ]
Zheng XueBin [2 ]
Zhang Yan [1 ]
Chen YiKai [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthopaed, Shanghai 200233, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Ceram, Shanghai 200050, Peoples R China
来源：
CHINESE SCIENCE BULLETIN | 2009年 / 54卷 / 23期
关键词：
hydroxyapatite coating; silver; plasma spraying; antibacterial osteoblast; in vitro test; SOL-GEL METHOD; BACTERIAL BIOFILMS; BIOACTIVE GLASS; INFECTIONS; TITANIUM; EFFICACY; STRENGTH; RELEASE;
D O I：
10.1007/s11434-009-0175-6
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The objective of the present investigation was to characterize the antibacterial and osteogenic properties of plasma sprayed silver-containing hydroxyapatite (HA/Ag) coating in vitro. HA/Ag coating was deposited via vacuum plasma spraying. The concentration of silver ions released from HA/Ag coating, the efficacy of the HA/Ag coating against bacterial biofilm development, the effect of the HA/Ag coating on early adhesion and ossification of osteoblast cells in vitro was measured. The silver ion concentration released from the HA/Ag coating was between the minimum inhibitory concentration to bacteria and the cytotoxic concentration. Bacterial biofilm inhibition studies indicated an antibacterial activity on the HA/Ag coating surface when compared with hydroxyapatite (HA) coating alone. Moreover, it was demonstrated that osteoblast cell adhesion and mineralization occurred on the HA/Ag coating surface during the testing period. We conclude that the vacuum plasma sprayed HA/Ag coating possesses good antibacterial capability and osteogenic properties in vitro and represents a promising candidate for coating orthopedic implants.
引用
收藏
页码：4438 / 4445
页数：8
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