Smoking and pancreatic disorders

被引：34
作者：
Chowdhury, P [1 ]
Rayford, PL [1 ]
机构：
[1] Univ Arkansas Med Sci, Little Rock, AR 72205 USA
来源：
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2000年 / 12卷 / 08期
关键词：
cigarette smoking; mechanism of action; nicotine; pancreatic acinar cells; pancreatic cancer; pancreatitis;
D O I：
10.1097/00042737-200012080-00006
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Cigarette smoking is a major risk factor for pancreatic cancer and probably pancreatitis. It has been reported that patients with chronic pancreatitis are 16 times more likely to develop pancreatic cancer than normal individuals. Nicotine, a major component of tobacco and an addicted drug of abuse in humans, appears to play a role in the aetiology of both pancreatic cancer and pancreatitis. This review discusses major published reports pertaining to the influence of nicotine on these diseases in humans and the probable effects of nicotine on the pathophysiology of the pancreas in animal models. A hypothetical pancreatic acinar cell model showing multiple signal transduction pathways is presented relating to possible mechanisms of action of nicotine on the pathophysiology of the pancreas. (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码：869 / 877
页数：9
相关论文
共 155 条
[1]   CERULEIN-INDUCED PANCREATITIS IN RATS - INCREASED LYSOSOMAL-ENZYME ACTIVITY AND AUTOPHAGOCYTOSIS [J].
ADLER, G ;
HAHN, C ;
KERN, HF ;
RAO, KN .
DIGESTION, 1985, 32 (01) :10-18
[2]  
*AM CANC SOC, 1996, AM CANC SOC FACTS FI
[3]  
ANDRIULLI A, 1983, AM J GASTROENTEROL, V78, P579
[4]  
[Anonymous], DHHS PUBL
[5]  
BELINSKY SA, 1986, CANCER RES, V46, P1280
[6]  
Benowitz N L, 1997, NIDA Res Monogr, V173, P48
[7]   SMOKERS OF LOW-YIELD CIGARETTES DO NOT CONSUME LESS NICOTINE [J].
BENOWITZ, NL ;
HALL, SM ;
HERNING, RI ;
JACOB, P ;
JONES, RT ;
OSMAN, AL .
NEW ENGLAND JOURNAL OF MEDICINE, 1983, 309 (03) :139-142
[8]   Cigarette smoking [J].
Bergen, AW ;
Caporaso, N .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (16) :1365-1375
[9]  
Blanck HM, 1999, ENVIRON MOL MUTAGEN, V33, P111, DOI 10.1002/(SICI)1098-2280(1999)33:2<111::AID-EM3>3.0.CO
[10]  
2-F
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