The combination of docetaxel and cisplatin plus fluorouracil as neoadjuvant chemotherapy in the treatment of T4 stage gastric cancer

被引：6
作者：
Guo, Ming-Gao [1 ]
Zheng, Qi [1 ]
Cheng, Zhe [1 ]
Wang, Yu [1 ]
Feng, Chang-Ning [1 ]
Yang, Zhe [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Peoples Hosp Shanghai 6, Dept Surg, Shanghai 200233, Peoples R China
来源：
SURGICAL ONCOLOGY-OXFORD | 2010年 / 19卷 / 01期
关键词：
Gastric cancer; Neoadjuvant Chemotherapy; Docetaxel; Cisplatin; Fluorouracil; Radical gastrectomy; SURGERY; CT;
D O I：
10.1016/j.suronc.2008.10.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The prognosis of local advanced gastric carcinoma is very poor. We evaluated the impact on survival and the effects induced by the triple combination docetaxel-cisplatin-fluorouracil (DCF) as neoadjuvant chemotherapy in 24 T4 stage gastric tumor patients. They received 2-3 cycles DCF chemotherapy, followed by radical gastric resection. Tumor downstaging detected by CT was obtained in 17 out of 24 patients. The overall 3-year survival rate was 68.2%. Patients who received R0 resection (19/22) showed a 3-year survival rate of 78.9%. T downstaged patients (17/22) showed a higher 3-year survival rate of 82.4%. Those who responded to the triple combination of docetaxel-cisplatin-fluorouracil, exhibited T downstaging and subsequently received an R0 resection had a definitely better chance of a cure as compared to surgery atone, according to a complete 3-year follow-up. (C) 2008 Elsevier Ltd. All rights reserved.
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页码：1 / 3
页数：3
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