Translating Electronic Currents to Precise Acetylcholine-Induced Neuronal Signaling Using an Organic Electrophoretic Delivery Device

被引：100

作者：

Tybrandt, Klas ^{[2
]}

Larsson, Karin C. ^{[1
]}

Kurup, Sindhulakshmi ^{[1
]}

Simon, Daniel T. ^{[2
]}

Kjall, Peter ^{[1
]}

Isaksson, Joakim ^{[2
]}

Sandberg, Mats ^{[3
]}

Jager, Edwin W. H. ^{[2
]}

Richter-Dahlfors, Agneta ^{[1
]}

Berggren, Magnus ^{[2
]}

机构：

[1] Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden

[2] Linkoping Univ, ITN, SE-60174 Norrkoping, Sweden

[3] Acreo AB, SE-60221 Norrkoping, Sweden

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 44期

关键词：

CONTROLLED DRUG-DELIVERY; POLYPYRROLE; RELEASE; CELLS; MEMBRANE; VALVES; STIMULATION; RECEPTORS; SYSTEM; FILMS;

D O I：

10.1002/adma.200900187

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A miniaturized organic electronic ion pump (OEIP) based on conjugated polymers is developed for delivery of positively charged biomolecules. Characterization shows that applied voltage can precisely modulate the delivery rate of the neurotransmitter acetylcholine. The capability of the device is demonstrated by convection-free, spatiotemporally resolved delivery of acetylcholine via a 10 mu m channel for dynamic stimulation of single neuronal cells.

引用

页码：4442 / +

页数：6

共 34 条

[1] Characterization of a membrane-based gradient generator for use in cell-signaling studies [J].

Abhyankar, VV ;

Lokuta, MA ;

Huttenlocher, A ;

Beebe, DJ .

LAB ON A CHIP, 2006, 6 (03) :389-393

[2] Conducting-polymer nanotubes for controlled drug release [J].

Abidian, MR ;

Kim, DH ;

Martin, DC .

ADVANCED MATERIALS, 2006, 18 (04) :405-+

[3]

AUGUSTINE GJ, 2008, NEUROSCIENCE, P90

[4] Calcium signalling: Dynamics, homeostasis and remodelling [J].

Berridge, MJ ;

Bootman, MD ;

Roderick, HL .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (07) :517-529

[5] The versatility and universality of calcium signalling [J].

Berridge, MJ ;

Lipp, P ;

Bootman, MD .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (01) :11-21

[6] AC electroosmotic pump with bubble-free palladium electrodes and rectifying polymer membrane valves [J].

Brask, A ;

Snakenborg, D ;

Kutter, JP ;

Bruus, H .

LAB ON A CHIP, 2006, 6 (02) :280-288

[7] Mechanotransduction at cell-matrix and cell-cell contacts [J].

Chen, CS ;

Tan, J ;

Tien, J .

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2004, 6 :275-302

[8] Nicotinic acetylcholine receptors and the regulation of neuronal signalling [J].

Dajas-Bailador, F ;

Wonnacott, S .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2004, 25 (06) :317-324

[9] Membranes and microfluidics: a review [J].

de Jong, J. ;

Lammertink, R. G. H. ;

Wessling, M. .

LAB ON A CHIP, 2006, 6 (09) :1125-1139

[10] Cholinergic stimulation of human microcitoma cell line H69 [J].

Fucile, S ;

Napolitano, M ;

Mattei, E .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 230 (03) :501-504

← 1 2 3 4 →