PALTEM: What Parameters Should Be Collected in Disaster Settings to Assess the Long-Term Outcomes of Famine?

被引：6

作者：

Moraru, Alexandra ^{[1
]}

de Almeida, Maria Moitinho ^{[1
]}

Degryse, Jean-Marie ^{[2
,3
]}

机构：

[1] Catholic Univ Louvain, Ctr Res Epidemiol Disasters, B-1200 Brussels, Belgium

[2] Catholic Univ Louvain, Inst Hlth & Soc, B-1200 Brussels, Belgium

[3] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, B-3000 Leuven, Belgium

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2018年 / 15卷 / 05期

关键词：

environmental epigenetics; DNA methylation; life-stage exposure; famine; risk assessment; BREAST-CANCER RISK; PRENATAL EXPOSURE; DUTCH FAMINE; EARLY-LIFE; DNA METHYLATION; CHINESE FAMINE; CALORIC RESTRICTION; CARDIOVASCULAR RISK; METABOLIC SYNDROME; IN-UTERO;

D O I：

10.3390/ijerph15050857

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Evidence suggests that nutritional status during fetal development and early life leaves an imprint on the genome, which leads to health outcomes not only on a person as an adult but also on his offspring. The purpose of this study is to bring forth an overview of the relevant parameters that need to be collected to assess the long-term and transgenerational health outcomes of famine. A literature search was conducted for the most pertinent articles on the epigenetic effects of famine. The results were compiled, synthesized and discussed with an expert in genetics for critical input and validation. Prenatal and early life exposure to famine was associated with metabolic, cardiovascular, respiratory, reproductive, neuropsychiatric and oncologic diseases. We propose a set of parameters to be collected in disaster settings to assess the long-term outcomes of famine: PALTEM (parameters to assess long-term effects of malnutrition).

引用

页数：32