Investigation on the association between NLRP3 gene polymorphisms and susceptibility to primary gout

被引：16
作者：
Wang, L. F. [1 ]
Ding, Y. J. [1 ]
Zhao, Q. [1 ]
Zhang, X. L. [2 ]
机构：
[1] Henan Univ, Dept Rheumatol, Huaihe Hosp, Kaifeng, Peoples R China
[2] Xinxiang Med Univ, Dept Nephropathy Rheumatol, Affiliated Hosp 3, Xinxiang, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 04期
关键词：
NLRP3; Polymorphism; Primary gout; AUTOINFLAMMATORY DISEASES; INFLAMMASOME; PATHOGENESIS;
D O I：
10.4238/2015.December.9.10
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We conducted a case-control study to investigate the association between 3 common NALP3 polymorphisms (rs10754558, rs7512998, and rs12137901) and the susceptibility to primary gout. A total of 320 patients with primary gout and 320 controls were included in this study. The genotyping of NALP3 rs10754558, rs7512998, and rs12137901 were conducted by polymerase chain reaction-restriction fragment length polymorphism. Comparison analysis showed that primary gout patients were more likely to have higher body mass index, prevalence of hypertension, blood glucose, triglycerides, urea nitrogen, and uric acid (P < 0.05). Logistic regression analysis revealed no significant association between the NALP3 rs10754558, rs7512998, and rs12137901 polymorphisms and the risk of gouty arthritis. In conclusion, we found no significant association between NALP3 gene polymorphisms and the risk of primary gout.
引用
收藏
页码：16410 / 16414
页数：5
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