Synthesis and antimicrobial activity of some quinoxaline derivatives

被引：6

作者：

El Janati, A. ^{[1
]}

Ouzidan, Y. ^{[2
]}

Rodi, Y. Kandri ^{[1
]}

Chandi, F. Ouazzani ^{[1
]}

Chraibi, M. ^{[3
]}

Benbrahim, K. Fikri ^{[3
]}

Alaoui, I. Cherif ^{[1
]}

El Hakmaoui, A. ^{[2
]}

Safi, M. ^{[2
]}

Akssira, M. ^{[2
]}

Elmsellem, H. ^{[4
]}

Essassi, E. M. ^{[5
]}

机构：

[1] Sidi Mohamed Ben Abdallah Univ, Fac Sci & Technol, Lab Appl Organ Chem, BP 2202, Fes, Morocco

[2] Hassan II Univ, Fac Sci & Technol, Lab Phys Chem & Bioorgan Chem, BP 146, Mohammadia 28800, Morocco

[3] Sidi Mohamed Ben Abdellah Univ, Fac Sci & Technol Saiss, Lab Microbial Biotechnol, Fes, Morocco

[4] Mohamed 1st Univ, Fac Sci, Dept Chem, LC2AME, POB 717, Oujda 60000, Morocco

[5] Mohammed V Univ Rabat, Fac Sci, Ctr Rech Sci Medicaments,URAC 21, Pole Competences Pharmacochim,Lab Chim Organ Hete, Ave Ibn Battouta,BP 1014, Rabat, Morocco

来源：

MOROCCAN JOURNAL OF CHEMISTRY | 2021年 / 9卷 / 02期

关键词：

Quinoxaline-2,3-dione; Alkylation; phase transfer catalysis; Antibacterial activity; PROFILE;

D O I：

10.48317/IMIST.PRSM/morjchem-v9i2.25855

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Some new structural motifs containing the quinoxaline nucleus have been synthesized and examined for their pharmacological properties. In this study, 6-chloroquinoxaline-2,3(1H, 4H)-dione and 6 nitroquinoxaline-2,3(1H, 4H)-dione were synthesized as basic nuclei for the preparation of the new quinoxaline-2,3-diones by alkylation reactions under the conditions of phase transfer catalysis. The products were characterized by spectroscopic methods H-1 and C-13 NMR. Then, the synthesized products were tested for their antibacterial effects against two bacterial strains. The values of minimum inhibitory concentrations (MIC) vary according to the nature of the alkyl bonded to the quinoxaline nucleus.

引用

页码：346 / 353

页数：8

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