Epigenetic Mechanisms Dictating Eradication of Cancer by Natural Killer Cells

被引：25

作者：

Bugide, Suresh ^{[1
]}

Janostiak, Radoslav ^{[1
]}

Wajapeyee, Narendra ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

[2] Yale Univ, Yale Canc Ctr, Sch Med, New Haven, CT 06510 USA

来源：

TRENDS IN CANCER | 2018年 / 4卷 / 08期

基金：

美国国家卫生研究院;

关键词：

NK CELLS; TUMOR-CELLS; HEPATOCELLULAR-CARCINOMA; DEVELOPMENTAL PATHWAYS; INHIBITORY RECEPTORS; NKG2D LIGANDS; T-CELLS; EXPRESSION; ACTIVATION; HISTONE;

D O I：

10.1016/j.trecan.2018.06.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Natural killer (NK) cells of the innate immune system are the first line of defense against infectious agents and cancer cells. However, only a few mechanisms that regulate eradication of tumors by NK cells have been identified. In this review, we present an account of epigenetic mechanisms that modulate the ability of NK cells to eradicate cancer cells. To date, several drugs that target epigenetic modifiers have shown clinical efficacy in cancer. Therefore, once a given epigenetic modifier is validated as a regulator of NK cell function, it can be targeted for NK cell-based cancer immunotherapies.

引用

页码：553 / 566

页数：14

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