PAF-induced kinin B1 receptor in vivo up-regulation:: involvement of distinct kinase pathways

被引:0
|
作者
Fernandes, Elizabeth S.
Medeiros, Rodrigo
Campos, Maria M.
Calixto, Joao B.
机构
[1] Univ Fed Santa Catarina, Ctr Biol Sci, CCB, Dept Pharmacol, BR-88049 Florianopolis, SC, Brazil
[2] Pontificia Univ Catolica Rio Grande do Sul, Sch Dent, Porto Alegre, RS, Brazil
关键词
D O I
10.1007/BF03353886
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Platelet activating factor (PAF) is an important mediator in several pathophysiological processes. PAF receptor activation can causes a series of cellular and tissue modifications and can lead to the production and/or release of diverse molecules, including cytokines, chemokines and receptors, amongst others, which are capable of amplifying the inflammation. PAF can up-regulate kinin B, receptor expression by various mechanisms. In the present study, we show an additional mechanism by which PAF can lead to an in vivo up-regulation of B, receptors. Our results clearly show that the phosphorylation of both ERK1/2 and JNK MAPKinases is an important step for this event. However, the exact mechanisms (transcriptional and post- transcriptional) by which PAT can trigger kinase phosphorylation and then up-regulate the B, receptor require further investigation.
引用
收藏
页码:S488 / S491
页数:4
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