PAF-induced kinin B1 receptor in vivo up-regulation:: involvement of distinct kinase pathways

被引:0
|
作者
Fernandes, Elizabeth S.
Medeiros, Rodrigo
Campos, Maria M.
Calixto, Joao B.
机构
[1] Univ Fed Santa Catarina, Ctr Biol Sci, CCB, Dept Pharmacol, BR-88049 Florianopolis, SC, Brazil
[2] Pontificia Univ Catolica Rio Grande do Sul, Sch Dent, Porto Alegre, RS, Brazil
关键词
D O I
10.1007/BF03353886
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Platelet activating factor (PAF) is an important mediator in several pathophysiological processes. PAF receptor activation can causes a series of cellular and tissue modifications and can lead to the production and/or release of diverse molecules, including cytokines, chemokines and receptors, amongst others, which are capable of amplifying the inflammation. PAF can up-regulate kinin B, receptor expression by various mechanisms. In the present study, we show an additional mechanism by which PAF can lead to an in vivo up-regulation of B, receptors. Our results clearly show that the phosphorylation of both ERK1/2 and JNK MAPKinases is an important step for this event. However, the exact mechanisms (transcriptional and post- transcriptional) by which PAT can trigger kinase phosphorylation and then up-regulate the B, receptor require further investigation.
引用
收藏
页码:S488 / S491
页数:4
相关论文
共 50 条
  • [21] Kinin B1 receptor antagonists inhibit diabetes-induced hyperalgesia in mice
    Gabra, BH
    Sirois, P
    NEUROPEPTIDES, 2003, 37 (01) : 36 - 44
  • [22] DELETION AND BLOCKAGE OF KININ B1 RECEPTOR EXACERBATES CISPLATIN-INDUCED CKD
    Estrela, Gabriel
    Budu, Alexandre
    Freitas-Lima, Leandro
    Arruda, Adriano
    Perilhao, Mauro
    Barrera-Chimal, Jonatan
    Araujo, Ronaldo
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2021, 36
  • [23] Inflammatory muscle pain is dependent on the activation of kinin B1 and B2 receptors and intracellular kinase pathways
    Meotti, F. C.
    Campos, R.
    da Silva, K. A. B. S.
    Paszcuk, A. F.
    Costa, R.
    Calixto, J. B.
    BRITISH JOURNAL OF PHARMACOLOGY, 2012, 166 (03) : 1127 - 1139
  • [24] Role of the B1 kinin receptor in the regulation of cardiac function and remodeling after myocardial infarction
    Xu, J
    Carretero, OA
    Sun, Y
    Shesely, EG
    Rhaleb, NE
    Liu, YH
    Liao, TD
    Yang, JJ
    Bader, M
    Yang, XP
    HYPERTENSION, 2005, 45 (04) : 747 - 753
  • [25] Involvement of the Kinin B1 Receptor in Increased Permeability of Cerebral Microvessels in Rats Subjected to Autoimmune Encephalomyelitis
    Sulkowski, Grzegorz
    Dabrowska-Bouta, Beata
    Frontczak-Baniewicz, Malgorzata
    Struzynska, Lidia
    CELLS, 2024, 13 (19)
  • [26] Molecular structure and transcriptional regulation by nuclear factor-κB of the mouse kinin B1 receptor gene
    Merino, VF
    Silva, JA
    Araujo, RC
    Avellar, MCW
    Bascands, JL
    Schanstra, JP
    Paiva, ACM
    Bader, M
    Pesquero, JB
    BIOLOGICAL CHEMISTRY, 2005, 386 (06) : 515 - 522
  • [27] Involvement of the Bradykinin B1 Receptor in Microglial Activation: In Vitro and In Vivo Studies
    Asraf, Keren
    Torika, Nofar
    Danon, Abraham
    Fleisher-Berkovich, Sigal
    FRONTIERS IN ENDOCRINOLOGY, 2017, 8
  • [28] Agonist-induced translocation of the kinin B1 receptor to caveolae-related rafts
    Sabourin, T
    Bastien, L
    Bachvarov, DR
    Marceau, F
    MOLECULAR PHARMACOLOGY, 2002, 61 (03) : 546 - 553
  • [29] Kinin B1 Receptor Is Involved in Angiotensin II-Induced Hypertrophy in Aorta of Rats
    Ceravolo, Graziela S.
    Jordao, Maria T.
    Akamine, Eliana H.
    Tostes, Rita C.
    Fortes, Zuleica B.
    Chopard, Renato P.
    Carvalho, Maria H.
    HYPERTENSION, 2009, 54 (04) : E118 - E118
  • [30] Brain Kinin B1 Receptor Antagonism Attenuates Angiotensin II -Induced Neurogenic Hypertension
    Parekh, Rohan U.
    Sriramula, Srinivas
    FASEB JOURNAL, 2022, 36