First-trimester fetal heart rate in mothers with opioid addiction

被引:20
作者
Schmid, Maximilian [1 ]
Kuessel, Lorenz [1 ]
Klein, Katharina [1 ]
Metz, Verena [2 ]
Fischer, Gabriele [2 ]
Krampl-Bettelheim, Elisabeth [1 ]
机构
[1] Med Univ Vienna, Dept Obstet & Fetomaternal Med, Vienna, Austria
[2] Med Univ Vienna, Dept Psychiat & Psychotherapy, Vienna, Austria
关键词
Fetal heart rate; first trimester; opioid addiction; pregnancy; ultrasound; NUCHAL-TRANSLUCENCY; 1ST TRIMESTER; MATERNAL AGE; METHADONE; PREGNANCY; TRISOMY-21; BLOCK;
D O I
10.1111/j.1360-0443.2010.02982.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Aim To investigate the difference in fetal heart rate of opioid-dependent mothers compared to non-dependent mothers in the first trimester of pregnancy. Design The data of 74 consecutive singleton pregnancies of mothers enrolled in a maintenance programme for opioid-dependent women was matched to 74 non-exposed singleton pregnancies by maternal age, crown-rump length, smoking status, ethnic background and mode of conception. Measurement Fetal heart rate measured as part of first-trimester screening by Doppler ultrasound between 11+0 and 13+6 gestational weeks was compared retrospectively. Findings The mean fetal heart rate in opioid-dependent mothers was 156.0 beats per minute (standard deviation 7.3) compared to 159.6 (6.5) in controls. The difference in fetal heart rate was significant (P = 0.02). There was a significant difference in mean maternal body mass index (P = 0.01) but not in mean nuchal translucency (P = 0.3), gestational age (0.5), fetal gender (P = 0.3) and parity (P = 0.3) between both groups. Fifty-five per cent (41 of 74) of cases were taking methadone, 30% (22 of 74) buprenorphine and 15% (11 of 74) were taking slow-release morphines throughout the pregnancy. Conclusions In fetuses of opioid-dependent mothers a decreased fetal heart rate can already be observed between 11+0 and 13+6 gestational weeks. The effect of opioid intake needs to be taken into consideration when interpreting fetal heart rate in opioid-dependent mothers at first-trimester screening.
引用
收藏
页码:1265 / 1268
页数:4
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