Ceramides and Barrier Function in Healthy Skin

被引：26

作者：

Jungersted, Jakob Mutanu ^{[1
,4
]}

Hellgren, Lars I. ^{[2
,3
]}

Hogh, Julie K. ^{[2
,3
]}

Drachmann, Tue ^{[2
,3
]}

Jemec, Gregor B. E. ^{[1
]}

Agner, Tove ^{[4
]}

机构：

[1] Univ Copenhagen, Roskilde Hosp, Dept Dermatol, Roskilde, Denmark

[2] Tech Univ Denmark, Dept Syst Biol, DK-2800 Lyngby, Denmark

[3] Tech Univ Denmark, Ctr Adv Food Sci, DK-2800 Lyngby, Denmark

[4] Univ Copenhagen, Dept Dermatol, Bispebjerg Hosp, DK-2400 Copenhagen NV, Denmark

来源：

ACTA DERMATO-VENEREOLOGICA | 2010年 / 90卷 / 04期

基金：

英国医学研究理事会;

关键词：

age; ceramides; ceramide/cholesterol ratio; gender; stratum corneum; TEWL; STRATUM-CORNEUM; ATOPIC-DERMATITIS; LIPIDS; FILAGGRIN; AGE;

D O I：

10.2340/00015555-0894

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and ceramide/cholesterol ratios in young, old, male and female healthy skin. A total of 55 participants with healthy skin was included in the study. Lipid profiles were correlated with transepidermal water loss and with information on dry skin from a questionnaire including 16 people. No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p=0.02).

引用

页码：350 / 353

页数：4

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