Current status and future possibilities of nitric oxide-donor drugs:: Focus on S-nitrosothiols

被引：37
作者：
Al-Sa'doni, HH
Ferro, A
机构：
[1] Kings Coll London, St Thomas Hosp, Dept Clin Pharmacol, GKT,Sch Med,Cardiovasc Div, London SE1 7EH, England
[2] Al Al Bayt Univ, Dept Chem, Mafraq, Jordan
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 03期
关键词：
nitric oxide; nitric oxide donors; S-nitrosothiols; therapeutics;
D O I：
10.2174/1389557053175399
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Drugs which release nitric oxide (NO) have great therapeutic potential. The organic nitrates and sodium nitroprusside have been used in cardiovascular therapeutics for many years, but several drawbacks limit their usefulness. In this review, we consider novel and potential future developments in NO-donor drugs, and the possible clinical usefulness of such compounds.
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页码：247 / 254
页数：8
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