Current status and future possibilities of nitric oxide-donor drugs:: Focus on S-nitrosothiols

被引：37
作者：
Al-Sa'doni, HH
Ferro, A
机构：
[1] Kings Coll London, St Thomas Hosp, Dept Clin Pharmacol, GKT,Sch Med,Cardiovasc Div, London SE1 7EH, England
[2] Al Al Bayt Univ, Dept Chem, Mafraq, Jordan
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 03期
关键词：
nitric oxide; nitric oxide donors; S-nitrosothiols; therapeutics;
D O I：
10.2174/1389557053175399
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Drugs which release nitric oxide (NO) have great therapeutic potential. The organic nitrates and sodium nitroprusside have been used in cardiovascular therapeutics for many years, but several drawbacks limit their usefulness. In this review, we consider novel and potential future developments in NO-donor drugs, and the possible clinical usefulness of such compounds.
引用
收藏
页码：247 / 254
页数：8
相关论文
共 105 条
[1]   S-nitrosothiols:: a class of nitric oxide-donor drugs [J].
Al-Sa'doni, H ;
Ferro, A .
CLINICAL SCIENCE, 2000, 98 (05) :507-520
[2]   A novel family of S-nitrosothiols:: Chemical synthesis and biological actions [J].
Al-Sa'doni, HH ;
Khan, IY ;
Poston, L ;
Fisher, I ;
Ferro, A .
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2000, 4 (06) :550-560
[3]  
ALSTON TA, 1985, J BIOL CHEM, V260, P4069
[4]  
[Anonymous], J CHEM SOC PERK APR
[5]  
BALABAN AT, 1971, REV ROUM CHIM, V16, P721
[6]   NITRIC-OXIDE - A SIGNAL FOR ADP-RIBOSYLATION OF PROTEINS [J].
BRUNE, B ;
DIMMELER, S ;
VEDIA, LMY ;
LAPETINA, EG .
LIFE SCIENCES, 1994, 54 (02) :61-70
[7]   Nitric-oxide releasing molecules: A new class of drugs with several major indications [J].
Burgaud, JL ;
Riffaud, JP ;
Del Soldato, P .
CURRENT PHARMACEUTICAL DESIGN, 2002, 8 (03) :201-213
[8]   Synthesis, decomposition, and vasodilator action of some new S-nitrosated dipeptides [J].
Butler, AR ;
Al-Sa'doni, HH ;
Megson, IL ;
Flitney, FW .
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 1998, 2 (03) :193-202
[9]  
CLANCY RM, 1995, P SOC EXP BIOL MED, V210, P93
[10]   NITRIC-OXIDE REACTS WITH INTRACELLULAR GLUTATHIONE AND ACTIVATES THE HEXOSE-MONOPHOSPHATE SHUNT IN HUMAN NEUTROPHILS - EVIDENCE FOR S-NITROSOGLUTATHIONE AS A BIOACTIVE INTERMEDIARY [J].
CLANCY, RM ;
LEVARTOVSKY, D ;
LESZCZYNSKAPIZIAK, J ;
YEGUDIN, J ;
ABRAMSON, SB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :3680-3684
12345678910