Compounds from Viburnum sargentii Koehne and Evaluation of Their Cytotoxic Effects on Human Cancer Cell Lines

被引：12

作者：

Bae, Ki-Eun ^{[1
]}

Chong, Han-Soo ^{[1
]}

Kim, Dong-Sup ^{[1
]}

Choi, Young-Woong ^{[1
]}

Kim, Young-Sook ^{[1
]}

Kim, Young-Kyoon ^{[1
]}

机构：

[1] Kookmin Univ, Dept Forest Prod & Biotechnol, Coll Forest Sci, Seoul 136702, South Korea

来源：

MOLECULES | 2010年 / 15卷 / 07期

关键词：

Viburnum sargentii; Caprifoliaceae; furcatoside A; 9 '-O-methylvibsanol; lareciresinol; Cancer cells; antitumor activity; APOPTOSIS PATHWAYS; IRIDOID GLUCOSIDES; NATURAL-PRODUCTS;

D O I：

10.3390/molecules15074599

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Compounds were isolated from a methanol extract of the dried stem barks of Viburnum sargentii Koehne. The structures of the compounds, namely 9'-O-methylvibsanol (3), furcatoside A (4) and lareciresinol (5) were elucidated by analysis of spectroscopic data and comparison with values for previously known analogues. In addition, (+)-catechin (1), (+)-epicatechin (2) were also isolated. This work also examined the cytotoxic effects of three compounds 3-5 (25-100 mu M) in MCF-7 and A549 cells after 24, 48 and 72 h of exposure. Our results showed that 9'-O-methylvibsanol (3) exhibited strong concentration-dependent anticancer effects according to the MTT assay and produced morphological changes consistent with apoptosis, as confirmed by Ho3342 staining analysis revealed that more apoptotic cells were observed after 9'-O-methylvibsanol (3) treatment.

引用

页码：4599 / 4609

页数：11

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