A targeted extracorporeal therapy for endotoxemia: the time has come

被引：8

作者：

Kellum, John A. ^{[1
]}

机构：

[1] Univ Pittsburgh, CRISMA Lab, Pittsburgh, PA 15261 USA

来源：

CRITICAL CARE | 2007年 / 11卷 / 03期

关键词：

D O I：

10.1186/cc5918

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Endotoxemia, whether primary ( due to Gram-negative infection) or secondary ( due to epithelial barrier dysfunction), appears to be extremely common in the critically ill and injured. High levels of endotoxin activity are associated with worse clinical outcomes. In Japan, polymyxin B hemoperfusion has been available to treat endotoxemia for more than ten years. Multiple small trials, often limited by methodological quality, show that polymyxin B hemoperfusion may have favorable effects on survival and hemodynamics. Further study of this therapy would seem justified.

引用

页数：2

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