Roles of vimentin in health and disease

被引：125
作者：
Ridge, Karen M. [1 ,2 ]
Eriksson, John E. [3 ,4 ,5 ,6 ]
Pekny, Milos [7 ,8 ,9 ]
Goldman, Robert D. [1 ,2 ]
机构：
[1] Northwestern Univ, Div Pulm & Crit Care Med, Chicago, IL 60611 USA
[2] Northwestern Univ, Dept Cell & Dev Biol, Chicago, IL 60611 USA
[3] Abo Akad Univ, Fac Sci & Technol, Cell Biol, FIN-20521 Turku, Finland
[4] Univ Turku, Turku Biosci Ctr, FIN-20521 Turku, Finland
[5] Abo Akad Univ, FIN-20521 Turku, Finland
[6] Euro Bioimaging European Res Infrastruct Consorti, FIN-20521 Turku, Finland
[7] Univ Gothenburg, Lab Astrocyte Biol & CNS Regenerat, Ctr Brain Repair,Sahlgrenska Acad, Dept Clin Neurosci,Inst Neurosci & Physiol, S-41390 Gothenburg, Sweden
[8] Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3052, Australia
[9] Univ Newcastle, Newcastle, NSW 2300, Australia
来源：
GENES & DEVELOPMENT | 2022年 / 36卷 / 7-8期
基金：
英国医学研究理事会; 瑞典研究理事会; 美国国家卫生研究院; 芬兰科学院;
关键词：
intermediate filaments; vimentin; vimentin-null mouse; FIBRILLARY ACIDIC PROTEIN; HORMONE-SENSITIVE LIPASE; MICE LACKING VIMENTIN; INTERMEDIATE-FILAMENTS; REACTIVE ASTROCYTES; PULMONARY-FIBROSIS; RETINAL-DETACHMENT; OXIDATIVE STRESS; POOR-PROGNOSIS; MULLER CELLS;
D O I：
10.1101/gad.349358.122
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In this review, Ridge et al. discuss the essential functions of vimentin IFs revealed from studies of Vim(-/-) mice and cells derived from them. More than 27 yr ago, the vimentin knockout (Vim(-/-)) mouse was reported to develop and reproduce without an obvious phenotype, implying that this major cytoskeletal protein was nonessential. Subsequently, comprehensive and careful analyses have revealed numerous phenotypes in Vim(-/-) mice and their organs, tissues, and cells, frequently reflecting altered responses in the recovery of tissues following various insults or injuries. These findings have been supported by cell-based experiments demonstrating that vimentin intermediate filaments (IFs) play a critical role in regulating cell mechanics and are required to coordinate mechanosensing, transduction, signaling pathways, motility, and inflammatory responses. This review highlights the essential functions of vimentin IFs revealed from studies of Vim(-/-) mice and cells derived from them.
引用
收藏
页码：391 / 407
页数：17
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