DNA gyrase and topoisomerase IV are dual targets of zabofloxacin in Streptococcus pneumoniae

被引:18
作者
Park, Hee Soo [1 ]
Jung, Sung Ji [1 ]
Kwak, Jin-Hwan [1 ]
Choi, Dong-Rack [3 ]
Choi, Eung-Chil [2 ]
机构
[1] Handong Global Univ, Sch Life Sci, Pohang 791708, Kyungbuk, South Korea
[2] Seoul Natl Univ, Coll Pharm, Seoul, South Korea
[3] Dong Wha Pharmaceut Ind Ltd, Anyang, South Korea
关键词
IN-VITRO; DW-224A; FLUOROQUINOLONE; RESISTANCE; QUINOLONE;
D O I
10.1016/j.ijantimicag.2010.02.022
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
引用
收藏
页码:97 / 98
页数:3
相关论文
共 7 条
  • [1] Clinical and Laboratory Standards Institute, 2005, M100S15 CLSI
  • [2] Antimicrobial activity of DW-224a, a new fluoroquinolone, against Streptococcus pneumoniae
    Kim, Hyun-Joo
    Seol, Min-Jeong
    Park, Hee-Soo
    Choi, Dong-Rak
    Seong, Seung-Kyoo
    Shin, Hyun-Kil
    Kwak, Jin-Hwan
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 57 (06) : 1256 - 1258
  • [3] Antipneumococcal activity of DW-224a, a new quinolone, compared to those of eight other agents
    Kosowska-Shick, Klaudia
    Credito, Kim
    Pankuch, Glenn A.
    Lin, Gengrong
    Bozdogan, Bulent
    McGhee, Pamela
    Dewasse, Bonifacio
    Choi, Dong-Rack
    Ryu, Jei Man
    Appelbaum, Peter C.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (06) : 2064 - 2071
  • [4] In vitro and in vivo activities of DW-224a, a novel fluoroquinolone antibiotic agent
    Kwon, Ae-Ran
    Min, Yu-Hong
    Ryu, Jei-Man
    Choi, Dong-Rack
    Shim, Mi-Ja
    Choi, Eung-Chil
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (03) : 684 - 688
  • [5] Quinolone resistance mutations in Streptococcus pneumoniae GyrA and ParC proteins:: Mechanistic insights into quinolone action from enzymatic analysis, intracellular levels, and phenotypes of wild-type and mutant proteins
    Pan, XS
    Yague, G
    Fisher, LM
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (11) : 3140 - 3147
  • [6] In vitro and in vivo antibacterial activities of DW-224a, a new fluoronaphthyridone
    Park, Hee-Soo
    Kim, Hyun-Joo
    Seol, Min-Jung
    Choi, Dong-Rack
    Choi, Eung-Chil
    Kwak, Jin-Hwan
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (06) : 2261 - 2264
  • [7] Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection
    Ruiz, J
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (05) : 1109 - 1117