Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer

被引：86

作者：

Riquelme, Ismael ^{[1
]}

Letelier, Pablo ^{[2
]}

Riffo-Campos, Angela L. ^{[1
]}

Brebi, Priscilla ^{[1
]}

Carlos Roa, Juan ^{[3
]}

机构：

[1] Univ La Frontera, CEGIN BIOREN, Dept Pathol, Mol Pathol Lab, Ave Alemania 0458,3th Floor, Temuco 4810296, Chile

[2] Univ Catolica Temuco, Sch Hlth Sci, Manuel Montt 56, Temuco 4813302, Chile

[3] Pontificia Univ Catolica Chile, Adv Ctr Chron Dis ACCDiS, UC Ctr Invest Oncol CITO, Dept Pathol, Marcoleta 377,7th Floor, Santiago 8330024, Chile

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 03期

关键词：

microRNAs; drug resistance; gastric cancer; MODULATES MULTIDRUG-RESISTANCE; REGULATES CISPLATIN RESISTANCE; TARGETING IGF1R; P-GLYCOPROTEIN; CELL-LINES; MICRORNA; EXPRESSION; RNA; PATHWAY; PROTEIN;

D O I：

10.3390/ijms17030424

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastric cancer is the third leading cause of cancer mortality worldwide. Unfortunately, most gastric cancer cases are diagnosed in an advanced, non-curable stage and with a limited response to chemotherapy. Drug resistance is one of the most important causes of therapy failure in gastric cancer patients. Although the mechanisms of drug resistance have been broadly studied, the regulation of these mechanisms has not been completely understood. Accumulating evidence has recently highlighted the role of microRNAs in the development and maintenance of drug resistance due to their regulatory features in specific genes involved in the chemoresistant phenotype of malignancies, including gastric cancer. This review summarizes the current knowledge about the miRNAs' characteristics, their regulation of the genes involved in chemoresistance and their potential as targeted therapies for personalized treatment in resistant gastric cancer.

引用

页数：18

共 91 条

[1] miR-23b-3p regulates the chemoresistance of gastric cancer cells by targeting ATG12 and HMGB2 [J].

An, Y. ;

Zhang, Z. ;

Shang, Y. ;

Jiang, X. ;

Dong, J. ;

Yu, P. ;

Nie, Y. ;

Zhao, Q. .

CELL DEATH & DISEASE, 2015, 6 :e1766-e1766

[2] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[3] miRNA-based therapies: strategies and delivery platforms for oligonucleotide and non-oligonucleotide agents [J].

Baumann, Volker ;

Winkler, Johannes .

FUTURE MEDICINAL CHEMISTRY, 2014, 6 (17) :1967-1984

[4] Mammalian mirtron genes [J].

Berezikov, Eugene ;

Chung, Wei-Jen ;

Willis, Jason ;

Cuppen, Edwin ;

Lai, Eric C. .

MOLECULAR CELL, 2007, 28 (02) :328-336

[5] Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs [J].

Bohnsack, MT ;

Czaplinski, K ;

Görlich, D .

RNA, 2004, 10 (02) :185-191

[6] RNA polymerase III transcribes human microRNAs [J].

Borchert, Glen M. ;

Lanier, William ;

Davidson, Beverly L. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (12) :1097-1101

[7] Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo [J].

Boudreau, Ryan L. ;

Martins, Ines ;

Davidson, Beverly L. .

MOLECULAR THERAPY, 2009, 17 (01) :169-175

[8] The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance [J].

Casa, Angelo J. ;

Dearth, Robert K. ;

Litzenburger, Beate C. ;

Lee, Adrian V. ;

Cui, Xiaojiang .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2008, 13 :3273-3287

[9] Gastric cancer [J].

Catalano, Vincenzo ;

Labianca, Roberto ;

Beretta, Giordano D. ;

Gatta, Gemma ;

De Braud, Filippo ;

Van Cutsem, Eric .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2009, 71 (02) :127-164

[10] MicroRNAs modulate hematopoietic lineage differentiation [J].

Chen, CZ ;

Li, L ;

Lodish, HF ;

Bartel, DP .

SCIENCE, 2004, 303 (5654) :83-86

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