Midkine Regulation of the Renin-Angiotensin System

被引：11

作者：

Kadomatsu, Kenji ^{[1
]}

机构：

[1] Nagoya Univ, Dept Biochem, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668550, Japan

来源：

CURRENT HYPERTENSION REPORTS | 2010年 / 12卷 / 02期

关键词：

Chronic kidney disease; Hypertension; Midkine; Renin-angiotensin system; CHRONIC KIDNEY-DISEASE; RENAL-FAILURE; HYPERTENSION; INHIBITORS; RATIONALE; INJURY;

D O I：

10.1007/s11906-010-0092-8

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Hypertension and chronic kidney disease are often associated. The pathogenesis of these diseases involves the renin-angiotensin system. We have recently reported that the growth factor midkine is a novel regulator of the renin-angiotensin system. Midkine is a heparin-binding growth factor so far implicated in neuronal differentiation, neuroprotection, cardioprotection, inflammation, and cancer development. In a mouse model of chronic kidney disease induced by 5/6 nephrectomy, midkine is produced in the lung and in turn upregulates angiotensin-converting enzyme expression. Hypertension associated with 5/6 nephrectomy is not observed in midkine-deficient mice. Conversely, supplemental administration of midkine to the deficient mice induces hypertension. This review describes the molecular characteristics of midkine and its significance in the renin-angiotensin system and the kidney-lung interaction.

引用

页码：74 / 79

页数：6

共 18 条

[1] Cross-talk between the kidney and the cardiovascular system [J].

Amann, Kerstin ;

Wanner, Christoph ;

Ritz, Eberhard .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (08) :2112-2119

[2] Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts [J].

Banno, Hiroshi ;

Takei, Yoshifumi ;

Muramatsu, Takashi ;

Komori, Kimihiro ;

Kadomatsu, Kenji .

JOURNAL OF VASCULAR SURGERY, 2006, 44 (03) :633-641

[3] Prescribing angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in chronic kidney disease [J].

Ferrari, Paolo .

NEPHROLOGY, 2007, 12 (01) :81-89

[4] The growth factor midkine regulates the renin-angiotensin system in mice [J].

Hobo, Akinori ;

Yuzawa, Yukio ;

Kosugi, Tomoki ;

Kato, Noritoshi ;

Asai, Naoto ;

Sato, Waichi ;

Maruyama, Shoichi ;

Ito, Yasuhiko ;

Kobori, Hiroyuki ;

Ikematsu, Shinya ;

Nishiyama, Akira ;

Matsuo, Seiichi ;

Kadomatsu, Kenji .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (06) :1616-1625

[5] Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury [J].

Hoke, Thomas S. ;

Douglas, Ivor S. ;

Klein, Christina L. ;

He, Zhibin ;

Fang, Wenfeng ;

Thurman, Joshua M. ;

Tao, Yunxia ;

Dursun, Belda ;

Voelkel, Norbert F. ;

Edelstein, Charles L. ;

Faubel, Sarah .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2007, 18 (01) :155-164

[6] Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction [J].

Horiba, Mitsuru ;

Kadomatsu, Kenji ;

Yasui, Kenji ;

Lee, Jong-Kook ;

Takenaka, Hiroharu ;

Sumida, Arihiro ;

Kamiya, Kaichiro ;

Chen, Sen ;

Sakuma, Sadatoshi ;

Muramatsu, Takashi ;

Kodama, Itsuo .

CIRCULATION, 2006, 114 (16) :1713-1720

[7] Plasma midkine level is a prognostic factor for human neuroblastoma [J].

Ikematsu, Shinya ;

Nakagawara, Akira ;

Nakamura, Yohko ;

Ohira, Miki ;

Shinjo, Masaki ;

Kishida, Satoshi ;

Kadomatsu, Kenji .

CANCER SCIENCE, 2008, 99 (10) :2070-2074

[8] Midkine and pleiotrophin in neural development and cancer [J].

Kadomatsu, KJ ;

Muramatsu, T .

CANCER LETTERS, 2004, 204 (02) :127-143

[9]

Kaneda N, 1996, J BIOCHEM-TOKYO, V119, P1150

[10] Arterial Hypertension Induced by Erythropoietin and Erythropoiesis-Stimulating Agents (ESA) [J].

Krapf, Reto ;

Hulter, Henry N. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 4 (02) :470-480

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