Correlation between gel structural properties and drug release pattern in scleroglucan matrices

被引：17

作者：

Daraio, ME

François, N

Bernik, DL

机构：

[1] Univ Buenos Aires, INQUIMAE, RA-1428 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Ingn, Lab Quim Sistemas Heterogeneos, Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Fac Ingn, Lab Sistemas Liquidos, Buenos Aires, DF, Argentina

来源：

DRUG DELIVERY | 2003年 / 10卷 / 02期

关键词：

drug release; fluorescent molecular probes; hydrophilic matrices; scleroglucan;

D O I：

10.1080/713840361

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The drug delivery behavior of scleroglucan hydrogels was correlated with the structural features found by means of steady-state fluorescence studies. Theophylline at 0.4% in weight was used as the model drug and its release was measured using a Franz cell device. The results were fitted with a semi-empirical power law equation, finding significant differences between the 0.5% and higher than 0.8% scleroglucan concentrations (w/w). Four molecular fluorescent probes were used to test microenvironmental properties of the gel cavities, which will play a key role on the release of the pharmaceutical drugs. The results found by the fluorescence analysis are in good agreement with the ones obtained by release kinetics.

引用

页码：79 / 85

页数：7

共 27 条

[1]

ALHAIQUE F, 1993, PHARMAZIE, V48, P432

[2] Microviscosity of hydroxypropylcellulose gels as a basis for prediction of drug diffusion rates [J].