Personalised medicine in interstitial lung diseases

被引：17

作者：

Kokosi, Maria A. ^{[1
]}

Margaritopoulos, George A. ^{[1
]}

Wells, Athol U. ^{[1
]}

机构：

[1] Royal Brompton & Harefield NHS Fdn Trust, Interstitial Lung Dis Unit, Sydney St, London SW3 6NP, England

来源：

EUROPEAN RESPIRATORY REVIEW | 2018年 / 27卷 / 148期

关键词：

IDIOPATHIC PULMONARY-FIBROSIS; SURFACTANT PROTEIN-D; MUC5B PROMOTER POLYMORPHISM; BRONCHOALVEOLAR LAVAGE FLUID; REGULATORY T-CELLS; SYSTEMIC-SCLEROSIS; ACUTE EXACERBATION; TELOMERE LENGTH; CHITOTRIOSIDASE ACTIVITY; SERUM-LEVELS;

D O I：

10.1183/16000617.0117-2017

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Interstitial lung diseases in general, and idiopathic pulmonary fibrosis in particular, are complex disorders with multiple pathogenetic pathways, various disease behaviour profiles and different responses to treatment, all facets that make personalised medicine a highly attractive concept. Personalised medicine is aimed at describing distinct disease subsets taking into account individual lifestyle, environmental exposures, genetic profiles and molecular pathways. The cornerstone of personalised medicine is the identification of biomarkers that can be used to inform diagnosis, prognosis and treatment stratification. At present, no data exist validating a personalised approach in individual diseases. However, the importance of the goal amply justifies the characterisation of genotype and pathway signatures with a view to refining prognostic evaluation and trial design, with the ultimate aim of selecting treatments according to profiles in individual patients.

引用

页数：12

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