One-Pot Aminoalkylation of Aldehydes: Diastereoselective Synthesis of Vicinal Diamines with Azaarylmethylamines

被引：9

作者：

Guan, Haixing ^{[1
]}

Cao, Xianzhong ^{[1
]}

Walsh, Patrick J. ^{[2
]}

Mao, Jianyou ^{[1
]}

机构：

[1] Nanjing Tech Univ, Sch Chem & Mol Engn, Inst Adv Synth, 30 South Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China

[2] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, 231 South 34th St, Philadelphia, PA 19104 USA

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 21期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

STEREOSELECTIVE-SYNTHESIS; MANNICH REACTION; STEREOCONTROLLED SYNTHESIS; ORGANOMETALLIC REAGENTS; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; AMINATIVE UMPOLUNG; LITHIUM AMIDES; ALPHA; IMINES;

D O I：

10.1021/acs.orglett.9b03287

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot synthesis of vicinal diamines with azaarylmethylamines and aldehydes is reported. A diverse array of vicinal diamines could be achieved in up to 92% yield with good to excellent diastereoselectivities (up to 20:1). The tandem reaction takes place under mild conditions and provides an alternative strategy for the synthesis of vicinal diamines.

引用

页码：8679 / 8683

页数：5

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