Arsenic-induced myocardial injury: Protective role of Corchorus olitorius leaves

被引：40

作者：

Das, Anup K. ^{[1
]}

Sahu, Ranabir ^{[1
]}

Dua, Tarun K. ^{[1
]}

Bag, Sujit ^{[2
]}

Gangopadhyay, Moumita ^{[3
]}

Sinha, Mohit K. ^{[4
]}

Dewanjee, Saikat ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Pharmaceut Technol, Adv Pharmacognosy Res Lab, Kolkata 700032, India

[2] Seemanta Inst Pharmaceut Sci, Mayurbhanj, Orissa, India

[3] Bose Inst, Dept Bot, Med & Plant Res Lab, Kolkata, India

[4] Cent Res Inst Jute & Allied Fibers, Div Crop Improvement, Barakpur, India

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2010年 / 48卷 / 05期

关键词：

Corchorus olitorius; NaAsO2; Myocardial injury; Oxidative stress; REACTIVE OXYGEN; LIPID-PEROXIDATION; INDUCED TOXICITY; DRINKING-WATER; WEST-BENGAL; ACID; MECHANISMS; CONTAMINATION; ANTIOXIDANTS; PENTAVALENT;

D O I：

10.1016/j.fct.2010.02.012

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Groundwater arsenic contamination in Bangladesh and its adjoining part of West Bengal (India) is reported to be the biggest arsenic calamity in the world in terms of the affected population. Tossa jute, Corchorus olitorius is a popular crop of this arsenic prone population. The present study was undertaken to evaluate the protective effect of aqueous extract of C. olitorius leaves (AECO) against sodium arsenite (NaAsO2) induced cardiotoxicity in experimental rats. The animals exposed to NaAsO2 (10 mg/kg, p.o.) for 10 days exhibited a significant inhibition (p < 0.01) of superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase, glutathione reductase and reduced glutathione level in myocardial tissues of rats. In addition, it significantly increased (p < 0.01) oxidized glutathione, malondialdehyde and protein carbonyl content in myocardial tissue. Treatment with AECO (50 and 100 mg/kg, p.o.) for 15 days prior to NaAsO2-intoxication significantly protected cardiac tissue against arsenic-induced oxidative impairment. In addition, AECO pretreatment significantly prevented NaAsO2 induced hyperlipidemia, cardiac arsenic content and DNA fragmentation in experimental rats. Histological studies of myocardial tissue supported the protective activity of the AECO. The results concluded that the treatment with AECO prior to arsenic intoxication has significant protecting effect against arsenic-induced myocardial injury. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1210 / 1217

页数：8

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