Role of canonical Hedgehog signaling pathway in liver

被引：68
作者：
Gao, Lili [1 ]
Zhang, Zhenya [2 ]
Zhang, Peng [1 ]
Yu, Minghua [3 ]
Yang, Tao [1 ]
机构：
[1] Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Ctr Med Res & Innovat, 2800 Gongwei Rd, Shanghai 201399, Peoples R China
[2] Hebei Med Univ, Hosp 4, Dept Gen Surg, Shijiazhuang 050011, Hebei, Peoples R China
[3] Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Dept Oncol, Shanghai 201399, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2018年 / 14卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Hedgehog; liver; fibrosis; HCC; HEPATOCELLULAR-CARCINOMA CELLS; MOLECULAR TARGETED THERAPIES; TRANSGENIC MOUSE MODEL; HEPATIC STELLATE CELLS; REGENERATING RAT-LIVER; PARTIAL-HEPATECTOMY; ALPHA-FETOPROTEIN; MESSENGER-RNA; NONALCOHOLIC STEATOHEPATITIS; CHOLANGIOCELLULAR CARCINOMA;
D O I：
10.7150/ijbs.28089
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hedgehog (Hh) signaling pathway plays an important role in embryonic development. It becomes reactivated in many types of acute and chronic liver injuries. Hh signaling is required for liver regeneration, regulates capillarisation, controls the fates of hepatic stellate cells, promotes liver fibrosis and liver cancers. In this review, we summarize the current knowledge of the role of canonical Hh signaling pathway in adult liver. This help to understand the pathogenesis of liver diseases and find out the new effective targeted therapeutic strategies for liver diseases treatments.
引用
收藏
页码：1636 / 1644
页数：9
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