Severe eosinophilic asthma: a roadmap to consensus

被引：146

作者：

Buhl, Roland ^{[1
]}

Humbert, Marc ^{[2
]}

Bjermer, Leif ^{[3
]}

Chanez, Pascal ^{[4
]}

Heaney, Liam G. ^{[5
]}

Pavord, Ian ^{[6
]}

Quirce, Santiago ^{[7
]}

Virchow, Johann C. ^{[8
]}

Holgate, Stephen ^{[9
]}

机构：

[1] Mainz Univ Hosp, Dept Pulm Med, Mainz, Germany

[2] Univ Paris Sud, Dept Resp Med, Paris, France

[3] Skane Univ Hosp, Dept Resp Med & Allergol, Lund, Sweden

[4] Aix Marseille Univ, Dept Resp Med, Marseille, France

[5] Queens Univ Belfast, Dept Resp Med, Belfast, Antrim, North Ireland

[6] Univ Oxford, Nuffield Dept Med, Oxford, England

[7] La Paz Univ Hosp, Dept Allergy Med, Madrid, Spain

[8] Univ Rostock, Dept Pulm Med, Rostock, Germany

[9] Univ Southampton, Dept Clin & Expt Sci, Southampton, Hants, England

来源：

EUROPEAN RESPIRATORY JOURNAL | 2017年 / 49卷 / 05期

关键词：

MONOCLONAL-ANTIBODY; DOUBLE-BLIND; PLACEBO; BENRALIZUMAB; MULTICENTER; MEPOLIZUMAB; PHENOTYPES; RECEPTOR; DREAM;

D O I：

10.1183/13993003.00634-2017

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

[No abstract available]

引用

页数：6

共 26 条

[1] Treatable traits: toward precision medicine of chronic airway diseases [J].

Agusti, Alvar ;

Bel, Elisabeth ;

Thomas, Mike ;

Vogelmeier, Claus ;

Brusselle, Guy ;

Holgate, Stephen ;

Humbert, Marc ;

Jones, Paul ;

Gibson, Peter G. ;

Vestbo, Jorgen ;

Beasley, Richard ;

Pavord, Ian D. .

EUROPEAN RESPIRATORY JOURNAL, 2016, 47 (02) :410-419

[2] Do all asthmatics with atopy have atopic asthma? [J].

Arbes, Samuel J., Jr. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 130 (05) :1202-1204

[3]

Bel EH, 2014, NEW ENGL J MED, V371, P2434, DOI 10.1056/NEJMc1412892

[4] Reslizumab for Inadequately Controlled Asthma With Elevated Blood Eosinophil Levels A Randomized Phase 3 Study [J].

Bjermer, Leif ;

Lemiere, Catherine ;

Maspero, Jorge ;

Weiss, Sivan ;

Zangrilli, James ;

Germinaro, Matthew .

CHEST, 2016, 150 (04) :789-798

[5] Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial [J].

Bleecker, Eugene R. ;

FitzGerald, J. Mark ;

Chanez, Pascal ;

Papi, Alberto ;

Weinstein, Steven F. ;

Barker, Peter ;

Sproule, Stephanie ;

Gilmartin, Geoffrey ;

Aurivillius, Magnus ;

Werkstrom, Viktoria ;

Goldman, Mitchell .

LANCET, 2016, 388 (10056) :2115-2127

[6] Individually dosed omalizumab: an effective treatment for severe peanut allergy [J].

Brandstrom, J. ;

Vetander, M. ;

Lilja, G. ;

Johansson, S. G. O. ;

Sundqvist, A. -C. ;

Kalm, F. ;

Nilsson, C. ;

Nopp, A. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2017, 47 (04) :540-550

[7] Comparison of anti-interleukin-5 therapies in patients with severe asthma: global and indirect meta-analyses of randomized placebo-controlled trials [J].

Cabon, Y. ;

Molinari, N. ;

Marin, G. ;

Vachier, I. ;

Gamez, A. S. ;

Chanez, P. ;

Bourdin, A. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2017, 47 (01) :129-138

[8] Treatment for severe eosinophilic asthma-consistent effect of anti-interleukin-5 antibodies? [J].

Castro, Mario ;

Bacharier, Leonard B. .

LANCET, 2016, 388 (10056) :2059-2060

[9]

Castro M, 2015, LANCET RESP MED, V3, P355, DOI [10.1016/S2213-2600(15)00042-9, 10.1016/S2213-2600(15)00119-8]

[10] Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study [J].

Castro, Mario ;

Wenzel, Sally E. ;

Bleecker, Eugene R. ;

Pizzichini, Emilio ;

Kuna, Piotr ;

Busse, William W. ;

Gossage, David L. ;

Ward, Christine K. ;

Wu, Yanping ;

Wang, Bing ;

Khatry, Deepak B. ;

van der Merwe, Rene ;

Kolbeck, Roland ;

Molfino, Nestor A. ;

Raible, Donald G. .

LANCET RESPIRATORY MEDICINE, 2014, 2 (11) :879-890

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