Autoimmune Disorders of the Nervous System: Pathophysiology, Clinical Features, and Therapy

被引：47

作者：

Bhagavati, Satyakam ^{[1
]}

机构：

[1] Suny Downstate Med Ctr, Dept Neurol, Coll Med, New York, NY 11203 USA

来源：

FRONTIERS IN NEUROLOGY | 2021年 / 12卷

关键词：

autoimmunity; nervous system; clinical; therapy; pathophysiology; ASPARTATE RECEPTOR ENCEPHALITIS; MULTIPLE-SCLEROSIS; T-CELLS; MYASTHENIA-GRAVIS; ANTIBODIES; AUTOANTIBODIES; ANTIGEN; IMMUNOTHERAPY; DIAGNOSIS; ENCEPHALOMYELITIS;

D O I：

10.3389/fneur.2021.664664

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Remarkable discoveries over the last two decades have elucidated the autoimmune basis of several, previously poorly understood, neurological disorders. Autoimmune disorders of the nervous system may affect any part of the nervous system, including the brain and spinal cord (central nervous system, CNS) and also the peripheral nerves, neuromuscular junction and skeletal muscle (peripheral nervous system, PNS). This comprehensive overview of this rapidly evolving field presents the factors which may trigger breakdown of self-tolerance and development of autoimmune disease in some individuals. Then the pathophysiological basis and clinical features of autoimmune diseases of the nervous system are outlined, with an emphasis on the features which are important to recognize for accurate clinical diagnosis. Finally the latest therapies for autoimmune CNS and PNS disorders and their mechanisms of action and the most promising research avenues for targeted immunotherapy are discussed.

引用

页数：21

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