Lymphangiogenesis - New mechanisms

被引：50
作者：
Chang, L
Kaipainen, A
Folkman, J
机构：
[1] Childrens Hosp, Surg Res Lab, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA
来源：
LYMPHATIC CONTINUUM: LYMPHATIC BIOLOGY AND DISEASE | 2002年 / 979卷
关键词：
angiogenesis; lymphangiogenesis; bFGF; VEGF-A; VEGF-D; angiogenesis inhibitor; lymph angiogenesis inhibitor; lymphatic endothelial cells; blood vessel endothelial cells; murine cornea neovascularization;
D O I：
10.1111/j.1749-6632.2002.tb04872.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A mouse model has been developed to study lymphangiogenesis dissociated from angiogenesis. bFGF implanted in a mouse cornea at a concentration below the threshold to induce angiogenesis potently induces lymphangiogenesis. This model has permitted a study of cellular and molecular mechanisms of lymphangiogenesis.
引用
收藏
页码：111 / 119
页数：9
相关论文
共 19 条
  • [1] Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways
    Arbiser, JL
    Moses, MA
    Fernandez, CA
    Ghiso, N
    Cao, YH
    Klauber, N
    Frank, D
    Brownlee, M
    Flynn, E
    Parangi, S
    Byers, HR
    Folkman, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (03) : 861 - 866
  • [2] Essential role for oncogenic Ras in tumour maintenance
    Chin, L
    Tam, A
    Pomerantz, J
    Wong, M
    Holash, J
    Bardeesy, N
    Shen, Q
    O'Hagan, R
    Pantginis, J
    Zhou, H
    Horner, JW
    Cordon-Cardo, C
    Yancopoulos, GD
    DePinho, RA
    [J]. NATURE, 1999, 400 (6743) : 468 - 472
  • [3] Folkman J, 1985, Important Adv Oncol, P42
  • [4] FOLKMAN J, 2000, CANC MED, P32
  • [5] Folkman J., 2001, HARRISONS PRINCIPLES, V15th ed., P517
  • [6] GIMBRONE M A JR, 1973, Series Haematologica, V6, P453
  • [7] TUMOR-GROWTH AND NEOVASCULARIZATION - EXPERIMENTAL MODEL USING RABBIT CORNEA
    GIMBRONE, MA
    COTRAN, RS
    LEAPMAN, SB
    FOLKMAN, J
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1974, 52 (02) : 413 - 427
  • [8] DORMANCY OF MICROMETASTASES - BALANCED PROLIFERATION AND APOPTOSIS IN THE PRESENCE OF ANGIOGENESIS SUPPRESSION
    HOLMGREN, L
    OREILLY, MS
    FOLKMAN, J
    [J]. NATURE MEDICINE, 1995, 1 (02) : 149 - 153
  • [9] JAFFE EA, 1972, CIRCULATION, V46, P252
  • [10] EXPRESSION OF THE FMS-LIKE TYROSINE KINASE-4 GENE BECOMES RESTRICTED TO LYMPHATIC ENDOTHELIUM DURING DEVELOPMENT
    KAIPAINEN, A
    KORHONEN, J
    MUSTONEN, T
    VANHINSBERGH, VWM
    FANG, GH
    DUMONT, D
    BREITMAN, M
    ALITALO, K
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) : 3566 - 3570
12