Helicobacter pylori: Bacterial Factors and the Role of Cytokines in the Immune Response

被引:30
作者
Beatriz Romero-Adrian, Tania [1 ]
Leal-Montiel, Jorymar [1 ]
Monsalve-Castillo, Francisca [2 ]
Mengual-Moreno, Edgardo [1 ]
Garcia McGregor, Ernesto [3 ]
Perini, Lenis [3 ]
Antunez, Ana [3 ]
机构
[1] Univ Zulia, Inst Biol Res, Fac Med, Panamericano Sector, Maracaibo 4011, Venezuela
[2] Univ Zulia, Bioanal Sch, Fac Med, Maracaibo 4011, Venezuela
[3] Cent Hosp Dr Urquinaona, Rheumatol Unit, Maracaibo, Zulia, Venezuela
关键词
NECROSIS-FACTOR-ALPHA; GASTRIC EPITHELIAL-CELLS; OXIDATIVE DNA-DAMAGE; REGULATORY T-CELLS; GROWTH-FACTOR-BETA; VACUOLATING CYTOTOXIN; SERUM-LEVELS; INTERLEUKIN-1; POLYMORPHISMS; TYROSINE PHOSPHORYLATION; GENE POLYMORPHISMS;
D O I
10.1007/s00284-009-9518-4
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Helicobacter pylori is a gram-negative micro-aerophilic bacterium that is widely distributed geographically and causes chronic gastritis, peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. Bacterial virulence factors play an important role, since the virulent strains are more aggressive and increase the risk of developing severe clinical manifestations; in addition, other determinant factors are the nutritional state and the immune response of the host. Studies on humans, non-human primates, and rodents have reported that regulating proteins of the Th1 phenotype predominate in the immune response to the bacterial infection. The cytokines produced by this phenotype, are not very effective in eradicating the microorganism and furthermore, contribute to gastro-duodenal pathogenesis. Gastric inflammation in patients infected with H. pylori has been characterized by increased production of IL-1, IL-6, IL-12, IL-18, TNF-alpha, and IFN-gamma. Many prophylactic and therapeutic strategies have been researched using experimental animals. The utilization and effectiveness of vaccination on humans requires more study.
引用
收藏
页码:143 / 155
页数:13
相关论文
共 158 条
[1]   Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen [J].
Akbari, O ;
DeKruyff, RH ;
Umetsu, DT .
NATURE IMMUNOLOGY, 2001, 2 (08) :725-731
[2]   Helicobacter pylori-specific antibodies impair the development of gastritis, facilitate bacterial colonization, and counteract resistance against infection [J].
Akhiani, AA ;
Schön, K ;
Franzén, LE ;
Pappo, J ;
Lycke, N .
JOURNAL OF IMMUNOLOGY, 2004, 172 (08) :5024-5033
[3]   Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells [J].
Akhiani, AA ;
Pappo, J ;
Kabok, Z ;
Schön, K ;
Gao, W ;
Franzén, LE ;
Lycke, N .
JOURNAL OF IMMUNOLOGY, 2002, 169 (12) :6977-6984
[4]   Helicobacter pylori persistence:: An overview of interactions between H-pylori and host immune defenses [J].
Algood, Holly M. Scott ;
Cover, Timothy L. .
CLINICAL MICROBIOLOGY REVIEWS, 2006, 19 (04) :597-+
[5]   Virulent strains of Helicobacter pylori demonstrate delayed phagocytosis and stimulate homotypic phagosome fusion in macrophages [J].
Allen, LAH ;
Schlesinger, LS ;
Kang, B .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (01) :115-127
[6]   The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses [J].
Amedei, A ;
Cappon, A ;
Codolo, G ;
Cabrelle, A ;
Polenghi, A ;
Benagiano, M ;
Tasca, E ;
Azzurri, A ;
D'Elios, MM ;
Del Prete, G ;
de Bernard, M .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (04) :1092-1101
[7]   Helicobacter pylori enter and survive within multivesicular vacuoles of epithelial cells [J].
Amieva, MR ;
Salama, NR ;
Tompkins, LS ;
Falkow, S .
CELLULAR MICROBIOLOGY, 2002, 4 (10) :677-690
[8]   Cutting edge: Carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells [J].
Appelmelk, BJ ;
van Die, I ;
van Vliet, SJ ;
Vandenbroucke-Grauls, CMJE ;
Geijtenbeek, TBH ;
van Kooyk, Y .
JOURNAL OF IMMUNOLOGY, 2003, 170 (04) :1635-1639
[9]   Distribution of vacA genotypes in Helicobacter pylori strains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma [J].
Ashour, AAR ;
Magalhaes, PP ;
Mendes, EN ;
Collares, GB ;
de Gusmao, VR ;
Queiroz, DMM ;
Nogueira, AMMF ;
Rocha, GA ;
de Oliveira, CA .
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2002, 33 (03) :173-178
[10]   The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases [J].
Atherton, John C. .
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2006, 1 (01) :63-96