Small cell carcinoma of the esophagus. Report of five cases with a literature review

Small-cell carcinomas of the esophagus are a rare and aggressive tumors with early widespread dissemination. Despite the use of different therapeutic modalities, the prognosis remains poor Between 1993 and 1995, 5 patients with small-cell carcinoma of the esophagus weve treated at Rene-Gauducheau Center, representing 2.8% of all esophageal malignancies diagnosed during this period Three patients presented with limited disease while 2 patients had distant metastases dt the time of diagnosis. Primary treatment consisted of polychemotherapy in all patients and a complete response was observed in three cases. These 3 patients had received subsequent radiotherapy, and endoesophageal brachytherapy in 2 cases. In this article we report our experience of patients with this tumor and attempt to make comparisons with the cases published in the literature, regarding location, symptomatology, histopathologic diagnosis and treatment of this tumor. We conclude that the optimum treatment seems to be the same as for small-cell carcinoma of the lung, a multidrug combination chemotherapy regimen used alone or with sequential radiation.