Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease

被引:10
作者
Liu Chung Ming, Clara [1 ]
Sesperez, Kimberly [2 ]
Ben-Sefer, Eitan [1 ]
Arpon, David [1 ]
McGrath, Kristine [2 ]
McClements, Lana [2 ]
Gentile, Carmine [1 ,3 ,4 ]
机构
[1] Univ Technol Sydney, Sch Biomed Engn FEIT, Sydney, NSW 2007, Australia
[2] Univ Technol Sydney, Fac Sci, Sch Life Sci, Sydney, NSW 2007, Australia
[3] Univ Sydney, Sydney Med Sch, Sydney, NSW 2000, Australia
[4] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
关键词
preeclampsia; cardiovascular disease; heart failure; ischemic; reperfusion injury; in vivo model system; in vitro model system; ex vivo model system; LARGE ANIMAL-MODELS; IN-VITRO MODELS; TACHYCARDIA-INDUCED CARDIOMYOPATHY; EXPERIMENTAL ABRUPTIO PLACENTAE; ISCHEMIA-REPERFUSION INJURY; TUMOR-NECROSIS-FACTOR; MYOCARDIAL-ISCHEMIA; DRUG DISCOVERY; STEM-CELLS; TYROSINE KINASE-1;
D O I
10.3390/cells10040899
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of gestation, and is the leading cause of death for both mothers and babies in pregnancy. The pathophysiology remains poorly understood due to the variability and unpredictability of disease manifestation when studied in animal models. After preeclampsia, both mothers and offspring have a higher risk of cardiovascular disease (CVD), including myocardial infarction or heart attack and heart failure (HF). Myocardial infarction is an acute myocardial damage that can be treated through reperfusion; however, this therapeutic approach leads to ischemic/reperfusion injury (IRI), often leading to HF. In this review, we compared the current in vivo, in vitro and ex vivo model systems used to study preeclampsia, IRI and HF. Future studies aiming at evaluating CVD in preeclampsia patients could benefit from novel models that better mimic the complex scenario described in this article.
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页数:20
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