Nonalcoholic Fatty Liver Disease in Children Hepatic and Extrahepatic Complications

被引：30

作者：

Selvakumar, Praveen Kumar Conjeevaram ^{[1
]}

Kabbany, Mohammad Nasser ^{[1
]}

Nobili, Valerio ^{[2
]}

Alkhouri, Naim ^{[3
]}

机构：

[1] Cleveland Clin, Dept Pediat Gastroenterol & Hepatol, Cleveland, OH 44106 USA

[2] IRCCS Bambino Gesu Childrens Hosp, IRCCS, Liver Unit, Rome, Italy

[3] Cleveland Clin, Digest Dis Inst, Dept Pediat Gastroenterol & Hepatol, Cleveland Clin Main Campus,Mail Code A111, Cleveland, OH 44195 USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2017年 / 64卷 / 03期

关键词：

Nonalcoholic fatty liver disease; Extrahepatic complications; Hepatic complications; Metabolic syndrome; Obesity complications in children; OBSTRUCTIVE SLEEP-APNEA; INTIMA-MEDIA THICKNESS; VITAMIN-D STATUS; QUALITY-OF-LIFE; OBESE CHILDREN; METABOLIC SYNDROME; HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE; TRANSIENT ELASTOGRAPHY; CARDIOVASCULAR-DISEASE;

D O I：

10.1016/j.pcl.2017.01.008

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome and has become the most common form of chronic liver disease in children and adolescents. The histologic spectrum of NAFLD is broad ranging, from the relatively benign form of simple steatosis to the aggressive form of nonalcoholic steatohepatitis, eventually leading to fibrosis and cirrhosis. NAFLD has also been recognized as an independent risk factor for extrahepatic complications, such as cardiovascular disease, type 2 diabetes mellitus, sleep disorders, and osteoporosis. In this review, we discuss both the hepatic and extrahepatic complications of NAFLD in children.

引用

页码：659 / +

页数：18

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