Secondary infection with rhino-orbital cerebral mucormycosis associated with COVID-19

被引:65
作者
Dallalzadeh, Liane O. [1 ]
Ozzello, Daniel J. [1 ]
Liu, Catherine Y. [1 ]
Kikkawa, Don O. [1 ,2 ]
Korn, Bobby S. [1 ,2 ]
机构
[1] UC San Diego Shiley Eye Inst, Viterbi Family Dept Ophthalmol, Div Oculofacial Plast & Reconstruct Surg, 9415 Campus Point Dr, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Div Plast & Reconstruct Surg, Dept Surg, La Jolla, CA USA
来源
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY | 2022年 / 41卷 / 05期
关键词
COVID-19; invasive fungal sinusitis; mucormycosis; Sars-CoV-2;
D O I
10.1080/01676830.2021.1903044
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
We report two fatal cases of rhino-orbital-cerebral mucormycosis associated with COVID-19 infection. Both patients had pre-existing diabetes mellitus type 2, were treated with corticosteroids, and developed ketoacidosis. Both patients rapidly declined owing to rapid extension of the infection into the intracranial cavity. We postulate that additional risk factors for opportunistic fungal infection exist in COVID-19 patients including mechanical ventilation and Sars-CoV-2 induced immunosuppression. The ophthalmologist's role is particularly important in the early diagnosis of mucormycosis associated with COVID-19.
引用
收藏
页码:616 / 619
页数:4
相关论文
共 11 条
[1]  
Chen G., 2020, J CLIN INVEST, V130, P2620, DOI [DOI 10.1172/JCI137244, 10.1172/JCI137244, DOI 10.1101/2020.02.16.20023903]
[2]   COVID-19 and ENT Surgery [J].
Couloigner, V. ;
Schmerber, S. ;
Nicollas, R. ;
Coste, A. ;
Barry, B. ;
Makeieff, M. ;
Boudard, P. ;
Bequignon, E. ;
Morel, N. ;
Lescanne, E. .
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES, 2020, 137 (03) :161-166
[3]   Invasive fungal sinusitis: treatment of the orbit [J].
Kalin-Hajdu, Evan ;
Hirabayashi, Kristin E. ;
Vagefi, M. Reza ;
Kersten, Robert C. .
CURRENT OPINION IN OPHTHALMOLOGY, 2017, 28 (05) :522-533
[4]   Guidance for otolaryngology health care workers performing aerosol generating medical procedures during the COVID-19 pandemic [J].
Lammers, Marc J. W. ;
Lea, Jane ;
Westerberg, Brian D. .
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2020, 49 (01)
[5]   Rhino-Orbital Mucormycosis Associated With COVID-19 [J].
Mehta, Salil ;
Pandey, Abha .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2020, 12 (09)
[6]   Acute Invasive Rhino-Orbital Mucormycosis in a Patient With COVID-19-Associated Acute Respiratory Distress Syndrome [J].
Mekonnen, Zesemayat K. ;
Ashraf, Davin C. ;
Jankowski, Tyler ;
Grob, Seanna R. ;
Vagefi, M. Reza ;
Kersten, Robert C. ;
Simko, Jeffry P. ;
Winn, Bryan J. .
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY, 2021, 37 (02) :E40-E42
[7]   Recent Advances in the Pathogenesis of Mucormycoses [J].
Petrikkos, George ;
Tsioutis, Constantinos .
CLINICAL THERAPEUTICS, 2018, 40 (06) :894-902
[8]   Fungal Co-infections Associated with Global COVID-19 Pandemic: A Clinical and Diagnostic Perspective from China [J].
Song, Ge ;
Liang, Guanzhao ;
Liu, Weida .
MYCOPATHOLOGIA, 2020, 185 (04) :599-606
[9]  
The RECOVERY Collaborative Group, 2021, N Engl J Med, V384, P693, DOI [DOI 10.1056/NEJMOA2021436, DOI 10.1101/2020.06.22.20137273]
[10]   Orbital cellulitis, sinusitis and intracranial abnormalities in two adolescents with COVID-19 [J].
Turbin, Roger E. ;
Wawrzusin, Peter J. ;
Sakla, Nicole M. ;
Traba, Christin M. ;
Wong, Kristin G. ;
Mirani, Neena ;
Eloy, Jean A. ;
Nimchinsky, Esther A. .
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY, 2020, 39 (04) :305-310