Case Report: Predominant Tubulointerstitial Lupus Nephritis or the Combination With IgG4-Related Disease?

被引：3
作者：
Tan, Ying [1 ,2 ,3 ,4 ,5 ]
Qin, Yan [1 ,2 ,3 ,4 ,5 ,6 ]
Yu, Xiao-juan [1 ,2 ,3 ,4 ,5 ]
Xu, Rong [1 ,2 ,3 ,4 ,5 ]
Wang, Su-xia [1 ,2 ,3 ,4 ,5 ,7 ]
Zhou, Fu-de [1 ,2 ,3 ,4 ,5 ]
Zhao, Ming-hui [1 ,2 ,3 ,4 ,5 ,8 ]
机构：
[1] Peking Univ, Dept Med, Renal Div, Hosp 1, Beijing, Peoples R China
[2] Peking Univ, Inst Nephrol, Beijing, Peoples R China
[3] Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
[4] Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing, Peoples R China
[5] Chinese Acad Med Sci, Res Units Diag & Treatment Immune Mediated Kidney, Beijing, Peoples R China
[6] Second Peoples Hosp Shanxi Prov, Taiyuan, Peoples R China
[7] Peking Univ, Hosp 1, Lab Electron Microscopy, Pathol Ctr, Beijing, Peoples R China
[8] Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
来源：
FRONTIERS IN MEDICINE | 2021年 / 8卷
基金：
中国国家自然科学基金; 北京市自然科学基金;
关键词：
systemic lupus erythematosus; lupus nephritis; predominant interstitial nephritis; IgG3; storiform pattern; RHEUMATISM CLASSIFICATION CRITERIA; ACUTE-RENAL-FAILURE; INTERSTITIAL NEPHRITIS; RHEUMATOLOGY/EUROPEAN LEAGUE; AMERICAN-COLLEGE; PATIENT; ERYTHEMATOSUS;
D O I：
10.3389/fmed.2021.684889
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Isolated or dominant tubulointerstitial lupus nephritis is rare. Here, we reported a 67-year-old man diagnosed with systemic lupus erythematosus (SLE) based on clinical and laboratory criteria, who was showing impaired renal function and non-nephrotic range proteinuria in the past 2 years. Renal biopsy showed almost normal glomeruli, but the tubulointerstitium showed "storiform" pattern with interstitial infiltration of IgG3 predominant plasma cells. Immunofluorescence showed linear and granular staining of IgG and C1q along TBM and interstitium. He started on medium dose of oral steroids and mycophenolate mofetil, which were gradually tapered. As a result, his renal function improved over a few days. Now, he continued on low dose steroids and mycophenolate mofetil with no evidence of relapse.
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页数：5
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