Nutritional assessment and risk factors associated to malnutrition in patients with esophageal cancer

被引：87

作者：

Cao, Jingjing ^{[1
]}

Xu, Hongxia ^{[2
,3
]}

Li, Wei ^{[4
]}

Guo, Zengqing ^{[5
]}

Lin, Yuan ^{[6
]}

Shi, Yingying ^{[7
]}

Hu, Wen ^{[8
]}

Ba, Yi ^{[9
]}

Li, Suyi ^{[10
]}

Li, Zengning ^{[11
]}

Wang, Kunhua ^{[12
]}

Wu, Jing ^{[13
,14
]}

He, Ying ^{[15
]}

Yang, Jiajun ^{[16
]}

Xie, Conghua ^{[17
]}

Zhou, Fuxiang ^{[17
]}

Song, Xinxia ^{[18
]}

Chen, Gongyan ^{[19
]}

Ma, Wenjun ^{[20
]}

Luo, Suxia ^{[21
,22
]}

Chen, Zihua ^{[23
]}

Cong, Minghua ^{[24
]}

Ma, Hu ^{[25
]}

Zhou, Chunling ^{[26
]}

Wang, Wei ^{[27
]}

Luo, Qi ^{[28
]}

Shi, Yongmei ^{[29
]}

Qi, Yumei ^{[30
]}

Jiang, Haiping ^{[31
]}

Guan, Wenxian ^{[32
]}

Chen, Junqiang ^{[33
]}

Chen, Jiaxin ^{[34
]}

Fang, Yu ^{[35
]}

Zhou, Lan ^{[36
]}

Feng, Yongdong ^{[37
]}

Tan, Rongshao ^{[38
]}

Ou, Junwen ^{[39
]}

Zhao, Qingchuan ^{[40
]}

Wu, Jianxiong ^{[41
]}

Lin, Xin ^{[2
,3
]}

Yang, Liuqing ^{[42
]}

Fu, Zhenming ^{[43
]}

Wang, Chang ^{[4
]}

Deng, Li ^{[4
]}

Li, Tao ^{[44
]}

Song, Chunhua ^{[45
]}

Shi, Hanping ^{[42
]}

机构：

[1] Heze Med Coll, Dept Prevent Med, Heze 274000, Shandong, Peoples R China

[2] Third Mil Med Univ, Daping Hosp, Dept Nutr, Chongqing 400042, Peoples R China

[3] Third Mil Med Univ, Res Inst Surg, Chongqing 400042, Peoples R China

[4] First Hosp Jilin Univ, Canc Ctr, Changchun 130021, Jilin, Peoples R China

[5] Fujian Med Univ Canc Hosp, Fujian Canc Hosp, Dept Med Oncol, Fuzhou 350014, Fujian, Peoples R China

[6] Guangxi Med Univ, Affiliated Tumor Hosp, Dept Gastrointestinal Surg, Nanning 530021, Guangxi, Peoples R China

[7] SunYat Sen Univ, Affiliated Hosp 1, Dept Surg, Guangzhou 510080, Guangdong, Peoples R China

[8] Sichuan Univ, Dept Clin Nutr, West China Hosp, Chengdu 610041, Sichuan, Peoples R China

[9] Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Dept Gastrointestinal Oncol, Tianjin Key Lab Canc Prevent & Therapy,Dept Gastr, Tianjin 300060, Peoples R China

[10] Anhui Med Univ, Affiliated Prov Hosp, Dept Nutr & Metab Oncol, Hefei 230031, Anhui, Peoples R China

[11] Hebei Med Univ, Dept Clin Nutr, Hosp 1, Shijiazhuang 050031, Hebei, Peoples R China

[12] Kunming Med Univ, Affiliated Hosp 1, Inst Gastroenterol, Dept Gastrointestinal Surg, Kunming 650032, Yunnan, Peoples R China

[13] Guangdong Med Univ, Zhongshan Chenxinghai Hosp, Affiliated Zhongshan Chenxinghai Hosp, Zhongshan 528400, Guangdong, Peoples R China

[14] First Peoples Hosp Kashi, Dept Clin Nutr, Kashi 844000, Xinjiang, Peoples R China

[15] Chongqing Gen Hosp, Dept Clin Nutr, Chongqing 400014, Peoples R China

[16] Huizhou Municipal Cent Hosp, Dept Colorectal & Anal Surg, Huizhou 516001, Guangdong, Peoples R China

[17] Wuhan Univ, Dept Radiat & Med Oncol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China

[18] Hebei Med Univ, Xingtai Peoples Hosp, Dept Oncol, Xingtai 054031, Hebei, Peoples R China

[19] Harbin Med Univ, Dept 1, Tumor Hosp, Harbin 150085, Heilongjiang, Peoples R China

[20] Guangdong Acad Med Sci, Guangdong Gen Hosp, Dept Nutr, Guangzhou 510080, Guangdong, Peoples R China

[21] Zhengzhou Univ, Dept Oncol, Affiliated Canc Hosp, Zhengzhou 450008, Henan, Peoples R China

[22] Henan Canc Hosp, Zhengzhou 450008, Henan, Peoples R China

[23] Cent South Univ, Xiangya Hosp, Dept Gen Surg, Changsha 410008, Hunan, Peoples R China

[24] Chinese Acad Med Sci, Canc Hosp, Comprehens Oncol Dept, Beijing 100021, Peoples R China

[25] Zunyi Med Univ, Dept Oncol, Affiliated Hosp, Zunyi 563000, Guizhou, Peoples R China

[26] Harbin Med Univ, Affiliated Hosp 4, Harbin 150001, Heilongjiang, Peoples R China

[27] First Peoples Hosp Foshan, Canc Ctr, Foshan 528000, Guangdong, Peoples R China

[28] Xiamen Univ, Affiliated Hosp 1, Dept Gastrointestinal Tumor Surg, Xiamen 361003, Fujian, Peoples R China

[29] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Nutr, Sch Med, Shanghai 200025, Peoples R China

[30] Tianjin Third Cent Hosp, Dept Nutr, Tianjin 300170, Peoples R China

[31] Jinan Univ, Dept Surg, Affiliated Hosp 1, Guangzhou 510632, Guangdong, Peoples R China

[32] Nanjing Univ Med Sch, Affiliated Hosp, Dept Gen Surg, Nanjing Drum Tower Hosp, Nanjing 210008, Jiangsu, Peoples R China

[33] Guangxi Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Nanning 530021, Guangxi, Peoples R China

[34] Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Radiat & Med Oncol, Nanning 530021, Guangxi, Peoples R China

[35] Peking Univ Canc Hosp & Inst, Dept Clin Nutr, Beijing 100142, Peoples R China

[36] Tumor Hosp Yunnan Prov, Kunming Med Coll, Dept Nutr, Affiliated Hosp 3, Kunming 650118, Yunnan, Peoples R China

[37] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Surg, Wuhan 430030, Hubei, Peoples R China

[38] Guangzhou Red Cross Hosp, Dept Nutr, Guangzhou 510220, Guangdong, Peoples R China

[39] Guangzhou Univ Chinese Med, Clifford Hosp, Dept Clin Nutr, Guangzhou 510632, Guangdong, Peoples R China

[40] Fourth Mil Med Univ, Xijing Hosp, Dept Digest Dis, Xian 710032, Shanxi, Peoples R China

[41] Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Hepatobiliary Surg, Canc Hosp, Beijing 100021, Peoples R China

[42] Capital Med Univ, Beijing Shijitan Hosp, Clin Coll 9, Dept Gastrointestinal Surg Clin Nutr, PKU 10 Tieyi Rd, Beijing 100038, Peoples R China

[43] Wuhan Univ, Canc Ctr, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China

[44] Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr, Sch Med,Dept Radiotherapy, Chengdu 610041, Sichuan, Peoples R China

[45] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Stat, Zhengzhou 450001, Henan, Peoples R China

来源：

CURRENT PROBLEMS IN CANCER | 2021年 / 45卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Esophageal cancer; Nutrition status; Nutritional support; Risk factor; PG-SGA; KARNOFSKY PERFORMANCE STATUS; REACTIVE PROTEIN-LEVELS; SERUM-ALBUMIN; IMPACT; PROGNOSIS;

D O I：

10.1016/j.currproblcancer.2020.100638

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Esophageal cancer is the fourth most common cause of cancer death in China. Patients with esophageal cancer are more likely to suffer from malnutrition. The purpose of this study is to assess nu-tritional status of patients with esophageal cancer from multiple perspectives and analyze the risk factors. Methods: A total of 1482 esophageal cancer patients were enrolled in the study. We investigated the Scored Patient Generated Subjective Global Assessment (PG-SGA) scores, NRS-20 02 scores, Karnofsky performance status scores, anthropometric, and laboratory indicators of patients. Unconditional logistic regression anal-ysis was applied to identify the risk factors of nutritional status. Results: PG-SGA ( >4) and NRS-20 02 ( >3) showed the incidence of malnutrition were 76% and 50%, respectively. In the patients with PG-SGA score >4, the proportion of patients who did not receive any nutritional support was 60%. The incidence of mal-nutrition in females was significantly higher than that in males. Besides, abnormality rates of Red blood cell ( P < 0.001), MAC ( P = 0.037), and MAMC ( P < 0.001) in males was significantly higher than that in fe-males, while abnormality rates of TSF ( P < 0.001) was lower than that in females. After adjusted with the other potential risk factors listed, unconditional logistic regression analysis indicated smoking (odds ratio: 2.868, 95% confidence interval: 1.660-4.954), drinking (OR: 1.726, 95% CI: 1.099-2.712), family history (OR: 1.840, 95% CI: 1.132-2.992), radiotherapy or chemotherapy (OR: 1.594, 95% CI: 1.065-2.387), and pathologi-cal stage (OR: 2.263, 95% CI: 1.084-4.726) might be the risk factors of nutritional status, while nutritional support can reduce the risk of malnutrition. Conclusion: Effective nutritional risk assessment methods and nutritional intervention measures can be adopted according to the research data to improve quality of life of esophageal cancer patients. (c) 2020 Elsevier Inc. All rights reserved.

引用

页数：13

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