Blastomycosis

被引：89

作者：

Castillo, Caroline G. ^{[1
]}

Kauffman, Carol A. ^{[1
,2
]}

Miceli, Marisa H. ^{[1
]}

机构：

[1] Univ Michigan Hlth Syst, Div Infect Dis, 3119 Taubman Ctr, Ann Arbor, MI 48109 USA

[2] Vet Affairs Ann Arbor Healthcare Syst, Div Infect Dis, 2215 Fuller Rd, Ann Arbor, MI 48105 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2016年 / 30卷 / 01期

关键词：

Endemic mycoses; B dermatitidis; Blastomycosis; Fungal pneumonia; Amphotericin B; Itraconazole; ENDEMIC FUNGAL-INFECTIONS; OF-THE-LITERATURE; EXTRACORPOREAL MEMBRANE-OXYGENATION; RESPIRATORY-DISTRESS-SYNDROME; CENTRAL-NERVOUS-SYSTEM; IN-VITRO ACTIVITIES; REAL-TIME PCR; CASE SERIES; CEREBRAL BLASTOMYCOSIS; HISTOPLASMA-CAPSULATUM;

D O I：

10.1016/j.idc.2015.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Blastomycosis is an endemic fungal infection due to Blastomyces dermatitidis that most commonly causes pneumonia; but the organism can disseminate to any organ system, most commonly the skin, bones/joints, and genitourinary tract. Both immunocompetent and immunocompromised persons can be infected, but more severe disease occurs in the immunocompromised. Blastomycosis can be diagnosed by culture, direct visualization of the yeast in affected tissue, and/or antigen testing. Treatment course and duration depend on severity of illness. For mild to moderate pulmonary disease the treatment is itraconazole. For severe blastomycosis, lipid formulation amphotericin B is given, followed by step-down therapy with itraconazole.

引用

页码：247 / +

页数：19

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