A review of pharmacological and pharmacokinetic properties of Forsythiaside A

被引：75

作者：

Gong, Lihong ^{[1
]}

Wang, Cheng ^{[1
]}

Zhou, Honglin ^{[1
]}

Ma, Cheng ^{[1
]}

Zhang, Yafang ^{[1
]}

Peng, Cheng ^{[1
]}

Li, Yunxia ^{[1
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Key Lab Standardizat Chinese Herbal Med,Minist Ed, Chengdu 611137, Peoples R China

来源：

PHARMACOLOGICAL RESEARCH | 2021年 / 169卷

基金：

中国国家自然科学基金;

关键词：

Forsythiaside A; Pharmacological and pharmacokinetic properties; Anti-inflammation; Antivirus; Neuroprotection; Antioxidant; NF-KAPPA-B; INFLUENZA-A VIRUS; TRADITIONAL CHINESE MEDICINE; INDUCED OXIDATIVE STRESS; SUSPENSA THUNB. VAHL; TOLL-LIKE RECEPTORS; RIG-I; INTESTINAL-ABSORPTION; ENDOPLASMIC-RETICULUM; SIGNALING PATHWAYS;

D O I：

10.1016/j.phrs.2021.105690

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Traditional Chinese medicine plays a significant role in the treatment of various diseases and has attracted increasing attention for clinical applications. Forsythiae Fructus, the dried fruit of Forsythia suspensa (Thunb.) Vahl, is a widely used Chinese medicinal herb in clinic for its extensive pharmacological activities. Forsythiaside A is the main active index component isolated from Forsythiae Fructus and possesses prominent bioactivities. Modern pharmacological studies have confirmed that Forsythiaside A exhibits significant activities in treating various diseases, including inflammation, virus infection, neurodegeneration, oxidative stress, liver injury, and bacterial infection. In this review, the pharmacological activities of Forsythiaside A have been comprehensively reviewed and summarized. According to the data, Forsythiaside A shows remarkable anti-inflammation, antivirus, neuroprotection, antioxidant, hepatoprotection, and antibacterial activities through regulating multiple signaling transduction pathways such as NF-kappa B, MAPK, JAK/STAT, Nrf2, RLRs, TRAF, TLR7, and ER stress. In addition, the toxicity and pharmacokinetic properties of Forsythiaside A are also discussed in this review, thus providing a solid foundation and evidence for further studies to explore novel effective drugs from Chinese medicine monomers.

引用

页数：12

共 161 条

[1] Pathogen recognition and innate immunity [J].