Downregulation of microR-147b represses the proliferation and invasion of thyroid carcinoma cells by inhibiting Wnt/β-catenin signaling via targeting SOX15

被引：12

作者：

Xu, Chongwen ^{[1
]}

Liu, Junsong ^{[1
]}

Yao, Xiaobao ^{[1
]}

Bai, Yanxia ^{[1
]}

Zhao, Qian ^{[1
]}

Zhao, Ruimin ^{[1
]}

Kou, Bo ^{[1
]}

Li, Honghui ^{[1
]}

Han, Peng ^{[1
]}

Wang, Xuan ^{[1
]}

Guo, Longwei ^{[2
]}

Zheng, Zhiwei ^{[3
]}

Zhang, Shaoqiang ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Otorhinolaryngol Head & Neck Surg, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Dept Radiat Oncol, Affiliated Hosp 1, Xian 710061, Shaanxi, Peoples R China

[3] Rizhao Peoples Hosp, Ward 3, Dept Gen Surg, 126 Taian Rd, Rizhao 276800, Shandong, Peoples R China

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2020年 / 501卷

关键词：

miR-147b; SOX15; Thyroid carcinoma; Wnt; POTENTIAL BIOMARKER; MICRORNA EXPRESSION; MAMMALIAN SOX15; CANCER; GENES;

D O I：

10.1016/j.mce.2019.110662

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

microRNA-147b (miR-147b) is a newly identified tumor-related miRNA that is dysregulated in multiple cancer types. Yet, the role of miR-147b in thyroid carcinoma remains unknown. Herein, we found that miR-147b expression was upregulated in thyroid carcinoma tissues and cell lines. miR-147b inhibition decreased the proliferation, colony formation, and invasion of thyroid carcinoma cells. The tumor suppressive gene SRY-related high-mobility-group box gene 15 (SOX15) was predicted as a miR-147b target gene. SOX15 expression was markedly decreased in thyroid carcinoma tissues and inversely correlated with the miR-147b expression. SOX15 overexpression repressed the proliferation and invasion of thyroid carcinoma cells associated with downregulation of Wnt/beta-catenin signaling. SOX15 knockdown abolished the miR-147b-inhibition-mediated antitumor effect miR-147b inhibition or SOX15 overexpression retarded the tumor growth of thyroid carcinoma cells in vivo. Overall, our study suggests that miR-147b inhibition restrains the proliferation and invasion of thyroid carcinoma cells through upregulation of SOX15 and inhibition of Wnt/beta-catenin signaling.

引用

页数：8