Store-operated CRAC channels: function in health and disease

被引：264

作者：

Parekh, Anant B. ^{[1
]}

机构：

[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2010年 / 9卷 / 05期

基金：

英国医学研究理事会;

关键词：

ACTIVATED CA2+ CHANNELS; CELL CYTOKINE PRODUCTION; CALCIUM SENSOR STIM1; CURRENT I-CRAC; T-CELL; INTRACELLULAR CA2+; MOLECULAR DETERMINANTS; LEUKOTRIENE RECEPTORS; INDEPENDENT MODES; POTENT INHIBITION;

D O I：

10.1038/nrd3136

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Elevation of cytosolic Ca2+ levels through the activation of store-operated Ca2+ release-activated Ca2+ (CRAC) channels is involved in mediating a disparate array of cellular responses. These include secretion, metabolism and gene expression, as well as cell growth and proliferation. Moreover, emerging evidence points to the involvement of aberrant CRAC channel activity in human diseases, such as certain types of immunodeficiency and autoimmunity disorders, allergy, and inflammatory bowel disease. This article summarizes recent advances in understanding the gating and function of CRAC channels, their links to human disease and key issues for the development of channel blockers.

引用

页码：399 / 410

页数：12

共 132 条

[1] ACETYLCHOLINE-RECEPTOR CHANNEL STRUCTURE PROBED IN CYSTEINE-SUBSTITUTION MUTANTS [J].

AKABAS, MH ;

STAUFFER, DA ;

XU, M ;

KARLIN, A .

SCIENCE, 1992, 258 (5080) :307-310

[2] Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses [J].

Baba, Yoshihiro ;

Nishida, Keigo ;

Fujii, Yoko ;

Hirano, Toshio ;

Hikida, Masaki ;

Kurosaki, Tomohiro .

NATURE IMMUNOLOGY, 2008, 9 (01) :81-88

[3] Permeation through store-operated CRAC channels in divalent-free solution: potential problems and implications for putative CRAC channelgenes [J].

Bakowski, D ;

Parekh, AB .

CELL CALCIUM, 2002, 32 (5-6) :379-391

[4] Monovalent cation permeability and Ca2+ block of the store-operated Ca2+ current ICRAC in rat basophilic leukemia cells [J].

Bakowski, D ;

Parekh, AB .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2002, 443 (5-6) :892-902

[5] Nasal polyps: Still more questions than answers [J].

Bateman, ND ;

Fahy, C ;

Woolford, TJ .

JOURNAL OF LARYNGOLOGY AND OTOLOGY, 2003, 117 (01) :1-9

[6] Modulation of plasma membrane calcium-ATPase activity by local calcium microdomains near CRAC channels in human T cells [J].

Bautista, DM ;

Lewis, RS .

JOURNAL OF PHYSIOLOGY-LONDON, 2004, 556 (03) :805-817

[7] Calcium signalling: Dynamics, homeostasis and remodelling [J].

Berridge, MJ ;

Bootman, MD ;

Roderick, HL .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (07) :517-529

[8] INOSITOL TRISPHOSPHATE AND CALCIUM SIGNALING [J].

BERRIDGE, MJ .

NATURE, 1993, 361 (6410) :315-325

[9] STIM1 Is a Calcium Sensor Specialized for Digital Signaling [J].

Bird, Gary S. ;

Hwang, Sung-Yong ;

Smyth, Jeremy T. ;

Fukushima, Miwako ;

Boyles, Rebecca R. ;

Putney, James W., Jr. .

CURRENT BIOLOGY, 2009, 19 (20) :1724-1729

[10] STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels [J].

Brandman, Onn ;

Liou, Jen ;

Park, Wei Sun ;

Meyer, Tobias .

CELL, 2007, 131 (07) :1327-1339

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