Th2 responses predominate during the early phases of infection in patients with localized cutaneous leishmaniasis and precede the development of Th1 responses

被引：30

作者：

Bourreau, E

Gardon, J

Pradinaud, R

Pascalis, H

Prévot-Linguet, G

Kariminia, A

Pascal, L

机构：

[1] Inst Pasteur, Serv Epidemiol, Cayenne 97306, French Guiana

[2] Ctr Hosp Andree Rosemon, EA 2188, Inst Guyanais Dermatol Trop, Cayenne, French Guiana

[3] Univ Antilles Guyane, Inst Enseignement Super Guyane, Cayenne, French Guiana

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 04期

关键词：

D O I：

10.1128/IAI.71.4.2244-2246.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intralesional Th2 responses preceded the development of Th1 responses in localized cutaneous leishmaniasis due to Leishmania guyanensis. Although the number of parasites increased in Th2 lesions, no correlation was found between the levels of cytokine expression and the number of parasites. In contrast, the decreased number of parasites in Th1 lesions is negatively correlated to gamma interferon expression.

引用

页码：2244 / 2246

页数：3

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