Synthesis of Acetamides from Aryl Amines and Acetonitrile by Diazotization under Metal-Free Conditions

被引：5

作者：

Zeng, Yao-Fu ^{[1
,2
]}

Li, Yi-Na ^{[1
]}

Zhang, Na-Na ^{[2
]}

Kang, Huan ^{[2
]}

Duan, Pan ^{[2
]}

Xiao, Fang ^{[1
]}

Guo, Yu ^{[1
,2
]}

Wen, Xianghao ^{[3
]}

机构：

[1] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China

[2] Univ South China, Sch Pharmaceut Sci, Hengyang 421001, Peoples R China

[3] Univ South China, Affiliated Nanhua Hosp, Hengyang 421001, Peoples R China

来源：

SYNLETT | 2019年 / 30卷 / 19期

关键词：

aryl amines; amidation; acetonitrile; diazotization; acetamides; coupling reaction; NITRILES; AMIDATION; ACYLATION; EFFICIENT; AMIDES; SALTS;

D O I：

10.1055/s-0039-1690237

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and metal-free coupling reaction has been developed that affords acetamides from the corresponding aryl amines and acetonitrile. This method tolerates a wide range of functional groups and is selective toward aryl amines. Preliminary mechanistic studies were conducted.

引用

页码：2169 / 2172

页数：4

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