Therapeutic monitoring of digoxin and antiepileptic drugs in Egypt and Saudi Arabia

被引：10

作者：

El Desoky, ES ^{[1
]}

Al-Ghamdi, HA

Halaby, FH

Al-Beshri, M

机构：

[1] Assiut Univ, Fac Med, Dept Pharmacol, Assiut, Egypt

[2] Minist Hlth, Toxicol Ctr, Jeddah, Saudi Arabia

来源：

THERAPEUTIC DRUG MONITORING | 2003年 / 25卷 / 02期

关键词：

therapeutic drug monitoring; developing countries; digoxin; antiepileptic drugs;

D O I：

10.1097/00007691-200304000-00011

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Retrospective analysis was undertaken of serum drug levels determined in 1996 of 580 Egyptian and 1299 Saudi samples and in 2001 of 2361 Saudi samples. Monitored drugs were digoxin, carbamazepine, phenytoin, and valproic acid. The therapeutic drug monitoring results in 1996 showed no differences between the two countries in the rates of subtherapeutic, therapeutic, or toxic drug levels. When the levels of all drugs relative to therapeutic ranges were compared between the 1996 and 2001 Saudi data, a significant decrease in the rate of potentially toxic levels was seen in 2001.

引用

页码：211 / 214

页数：4

共 11 条

[1] Spotlight on the continual applicability of routine plasma monitoring antiepileptic drugs in the treatment of epilepsy [J].