Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestis

被引：82

作者：

Hill, J ^{[1
]}

Copse, C ^{[1
]}

Leary, S ^{[1
]}

Stagg, AJ ^{[1
]}

Williamson, ED ^{[1
]}

Titball, RW ^{[1
]}

机构：

[1] Def Sci & Technol Lab, Salisbury SP4 0JQ, Wilts, England

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 04期

关键词：

D O I：

10.1128/IAI.71.4.2234-2238.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monoclonal antibodies specific for Yersinia pestis V antigen and F1 antigen, administered singly or in combination, protected mice in models of bubonic and pneumonic plague. Antibodies showed synergy when administered prophylactically and as a therapy 48 h postinfection. Monoclonal antibodies therefore have potential as a treatment for plague.

引用

页码：2234 / 2238

页数：5

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