Cu(i)-Catalyzed asymmetric exo-selective synthesis of substituted pyrrolidines via a 1,3-dipolar cycloaddition reaction

被引：8

作者：

Biswas, Rayhan G. ^{[1
]}

Ray, Sumit K. ^{[2
]}

Kannaujiya, Vinod K. ^{[1
]}

Unhale, Rajshekhar A. ^{[1
]}

Singh, Vinod K. ^{[3
]}

机构：

[1] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bhopal 462066, Madhya Pradesh, India

[2] Kharagpur Coll, Dept Chem, Paschim Medinipur 721305, W Bengal, India

[3] Indian Inst Technol Kanpur, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 21期

关键词：

ENANTIOSELECTIVE 3+2 CYCLOADDITION; AZOMETHINE YLIDES; CONSTRUCTION; DIASTEREO; DIPOLAROPHILES; DERIVATIVES; CATALYSTS; STEREOSELECTIVITY; COMPLEXES; FRAMEWORK;

D O I：

10.1039/d1ob00494h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An (R)-DM-BINAP/Cu(CH3CN)(4)BF4 complex catalyzed exo-selective asymmetric 1,3-dipolar cycloaddition (1,3-DCA) reaction of imino esters with alpha,beta-unsaturated pyrazoleamides has been developed. A series of highly functionalized pyrrolidines with multiple stereogenic centers were obtained with good yields and diastereoselectivities and excellent enantioselectivities (up to 99% ee).

引用

页码：4685 / 4690

页数：6

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